Paeoniflorin inhibits chronic restraint stress-induced progression of hepatocellular carcinoma through suppressing norepinephrine-induced activation of hepatic stellate cells via SRC/AKT/ERK pathways
Bibliographic Data
| ID | 14744415 |
|---|---|
| Authors | Yujun Luo (0000-0002-5149-6451, Second Military Medical University), Wanfu Lin (0000-0003-2483-3392, Second Military Medical University), Shuang Xiang (Second Military Medical University), Yuanrong Shi, Yehui Shi (0000-0001-9649-7119, Second Military Medical University), Meihuan Fu, Maoyong Fu (0000-0003-2645-9832, Second Military Medical University), Xiaofeng Zhai (0009-0001-2308-5794, Second Military Medical University), Changquan Ling (0000-0002-0037-4059, Second Military Medical University, corresponding author), Binbin Cheng (0000-0002-8321-130X, Second Military Medical University, corresponding author) |
| Year | 2025 |
| Volume | 344 |
| Pages | 119517 |
| Publication date | 2025-03-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Journal of Ethnopharmacology (JOURNAL) |
| Journal identifiers | ISSN: 0378-8741 • E-ISSN: 1872-7573 |
| Publisher | Elsevier BV (PUBLISHER) |
| DOI | 10.1016/j.jep.2025.119517 |
| PMID | 39971013 |
| OpenAlex | W4407633777 |
| Language | EN |
| References cited | 49 |
Chronic stress · Dopamine · Hepatic stellate cell · Hepatocellular carcinoma · MAPK/ERK pathway · Norepinephrine · Paeoniflorin · Phosphorylation · Protein kinase B · Proto-oncogene tyrosine-protein kinase Src · Receptor · Cancer Mechanisms and Therapy · Cancer, Stress, Anesthesia, and Immune Response · Chemistry · Medicine · Traditional Chinese Medicine Analysis · Biochemistry · Cancer Research · Endocrinology · Internal Medicine · Pharmacology
Global Cancer Statistics 2020
Identification of paeoniflorin from Paeonia lactiflora pall. As an inhibitor of tryptophan 2,3-dioxygenase and assessment of its pharmacological effects on depressive mice
Jiawei Taohe Chengqi Decoction attenuates hepatic fibrosis by preventing activation of HSCs through regulating Src/ERK/Smad3 signal pathway
| Highly cited | No |
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