Miao medicine Gu Yan Xiao tincture inhibits mTOR to stimulate chondrocyte autophagy in a rabbit model of osteoarthritis

Bibliographic Data

ID14745332
AuthorsHe Cai (0009-0006-0357-1492, Guiyang College of Traditional Chinese Medicine), Yuhao Zheng (0000-0003-0087-6005, Guiyang College of Traditional Chinese Medicine), Yin-ying Chen (0000-0002-4211-6015, Guiyang College of Traditional Chinese Medicine), Yinying Chen, Qing Lu (0000-0002-7943-966X, Guiyang College of Traditional Chinese Medicine), Wu Hong (0000-0001-9980-2481, Guiyang College of Traditional Chinese Medicine), Qiucheng Guo (0009-0003-4854-0524, Guiyang College of Traditional Chinese Medicine), Shuguang Zheng (Guiyang College of Traditional Chinese Medicine, corresponding author)
Year2024
Volume328
Pages118095
Publication date2024-06-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2024.118095
PMID38548121
OpenAlexW4393237022
LanguageEN
Citations received1
References cited68

Gu Yan Xiao tincture mitigates tissue injury in a rabbit model of osteoarthritis, at least in part by inhibiting mTOR and thereby promoting autophagy in chondrocytes. These results rationalize the use of the tincture not only against osteoarthritis but also potentially other diseases involving inhibition of autophagy in bones and joints

Apoptosis · Autophagy · Cartilage · Chondrocyte · Collagenase · Enzyme · Osteoarthritis · Pathology · PI3K/AKT/mTOR pathway · Signal transduction · Tincture (heraldry · Traditional medicine · Autophagy in Disease and Therapy · Chemistry · Medicine · Musculoskeletal synovial abnormalities and treatments · Osteoarthritis Treatment and Mechanisms · Anatomy · Biochemistry · Pharmacology

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