Huaxian formula prevents the progression of radiation-induced pulmonary fibrosis by inhibiting the pro-fibrotic effects of macrophages

Bibliographic Data

ID14745592
AuthorsJunyang Chen (0000-0002-5258-9035, University of Electronic Science and Technology of China), Pingjin Zou (0000-0003-0480-5263, University of Electronic Science and Technology of China), Li Quan (0000-0003-1866-3622), Quan Li (0000-0003-4734-7709, Chengdu University of Traditional Chinese Medicine), Cuicui Gong, Caiping Gong (Chengdu University of Traditional Chinese Medicine), Zengyi Fang (University of Electronic Science and Technology of China), Bing Lin (0000-0002-5905-9512, Chengdu University of Traditional Chinese Medicine, corresponding author), Jinyi Lang (0000-0002-5406-8671, Sichuan Cancer Hospital, corresponding author), Meihua Chen (0000-0003-2813-7423, Sichuan Cancer Hospital, corresponding author)
Year2025
Volume338
IssuePt 2
Pages119026
Publication date2025-02-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2024.119026
PMID39515679
OpenAlexW4404136299
LanguageEN
Citations received1
References cited39

HXF's preventive effects on RIPF involve multiple targets and mechanisms, including the modulation of Arg1, Mmp10, and Fgf23 expression. By inhibiting the pro-fibrotic capacity of macrophages, HXF suppresses fibroblast activation and collagen production, thereby alleviating lung fibrosis. These findings underscore the potential of HXF as a preventive strategy in managing RIPF

Fibrosis · In vitro · Macrophage · Pathology · Pulmonary fibrosis · Chemistry · Effects of Radiation Exposure · Hydrogen's biological and therapeutic effects · Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis · Medicine · Biochemistry · Pharmacology

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