Indigo naturalis and its component tryptanthrin exert anti-angiogenic effect by arresting cell cycle and inhibiting Akt and FAK signaling in human vascular endothelial cells
Bibliographic Data
| ID | 14745657 |
|---|---|
| Authors | Hsin-Ning Chang (Chang Gung University), Sheng-Teng Huang, Sheng‐Teng Huang (0000-0002-7495-6115, Chang Gung Memorial Hospital), Yuan-Chieh Yeh (0000-0002-9656-0269, Chang Gung Memorial Hospital), Hsin-Shih Wang, Hsin‐Shih Wang (Chang Gung University), Tzu-Hao Wang, Tzu‐Hao Wang (0000-0002-1418-7684, Chang Gung Memorial Hospital), Yi-Hong Wu (Chang Gung Memorial Hospital), Jong-Hwei S Pang, Jong‐Hwei S Pang (0000-0003-3432-0208, Chang Gung University, corresponding author) |
| Year | 2015 |
| Volume | 174 |
| Pages | 474-481 |
| Publication date | 2015-11-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Journal of Ethnopharmacology (JOURNAL) |
| Journal identifiers | ISSN: 0378-8741 • E-ISSN: 1872-7573 |
| Publisher | Elsevier BV (PUBLISHER) |
| DOI | 10.1016/j.jep.2015.08.050 |
| PMID | 26341616 |
| OpenAlex | W1482472850 |
| Language | EN |
| Citations received | 5 |
| References cited | 34 |
All together, these results demonstrated the anti-angiogenic effect of tryptanthrin, the acting component of indigo naturalis and revealed the underlying mechanism by inhibiting the cell cycle progression, cell migration and tube formation, likely mediated through blocking the Akt and FAK pathways
Angiogenesis · Apoptosis · Biology · Cell cycle · Chorioallantoic membrane · Cyclin A · Cyclin-dependent kinase · Endothelial stem cell · In vitro · Protein kinase B · Signal transduction · Bioactive Compounds and Antitumor Agents · Chemistry · Mast cells and histamine · Quinazolinone synthesis and applications · Biochemistry · Cancer Research · Cell Biology · Molecular Biology
Strobilanthes cusia (Nees) Kuntze, a multifunctional traditional Chinese medicinal plant, and its herbal medicines
Psoriasis treatment using Indigo Naturalis
The N-butyl alcohol extract from Hibiscus rosa-sinensis L. flowers enhances healing potential on rat excisional wounds
The anti-TH17 polarization effect of Indigo naturalis and tryptanthrin by differentially inhibiting cytokine expression
Indigenous knowledge of dye-yielding plants among Bai communities in Dali, Northwest Yunnan, China
| Unique citing works | 5 |
|---|---|
| Citations per year | 0,56 |
| Citation span | 2017 - 2022 (6) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 5 |