Stimulation of functional recovery via neurorepair mechanisms by the traditional Japanese Kampo medicine, Ninjin'yoeito, and physical exercise in a rat ischemic stroke model

Bibliographic Data

ID14745951
AuthorsAkira Tani (Kagoshima University), Harutoshi Sakakima (0000-0002-6805-2742, Kagoshima University, corresponding author), Shotaro Otsuka (0000-0003-3563-2473, Kagoshima University), Keita Mizuno (Tsumura Research Institute (Japan)), Kazuki Nakanishi (0009-0003-3621-7172, Kagoshima University), Kosuke Norimatsu (Kagoshima University), Seiya Takada (0000-0002-8960-7233, Kagoshima University), Teruki Matsuoka (Kagoshima University), Ryoma Matsuzaki (Kagoshima University), Tomomi Nakakogawa (Kagoshima University), Ikuro Maruyama (0000-0003-1571-0710, Kagoshima University)
Year2023
Volume302
IssuePt B
Pages115927
Publication date2023-02-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2022.115927
PMID36402237
OpenAlexW4309436599
LanguageEN
Citations received1
References cited36

This study suggests that NYT in combination with exercise provides neuroprotective effects and improves sensorimotor function by stimulating NGF/TrkA and BDNF/TrkB, and by activating the Akt pathway in ischemic stroke of rats. NYT may be an effective adjunctive agent in post-stroke rehabilitation

Anesthesia · Brain-derived neurotrophic factor · Neuroprotection · Neurotrophic factors · Physical therapy · Receptor · Stroke (engine · Stroke recovery · Medicinal Plants and Bioactive Compounds · Medicine · Neuroinflammation and Neurodegeneration Mechanisms · Neurological Disease Mechanisms and Treatments · Internal Medicine · Rehabilitation

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