Investigation of the anti-inflammatory, anti-pruritic, and analgesic effects of sophocarpine inhibiting TRP channels in a mouse model of inflammatory itch and pain
Bibliographic Data
| ID | 14746136 |
|---|---|
| Authors | Hekun Zeng (0000-0002-6644-7353, Ministry of Education), Zhe Zhang (0000-0003-3057-9490, Ministry of Education), Dan Zhou (0000-0001-8678-8270, Ministry of Education), Ranjing Wang (Ministry of Education), Alexei Verkhratsky (0000-0003-2592-9898, Ikerbasque), Hong Nie (0000-0002-7409-4260, Ministry of Education, corresponding author) |
| Year | 2025 |
| Volume | 337 |
| Issue | Pt 2 |
| Pages | 118882 |
| Publication date | 2025-01-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Journal of Ethnopharmacology (JOURNAL) |
| Journal identifiers | ISSN: 0378-8741 • E-ISSN: 1872-7573 |
| Publisher | Elsevier BV (PUBLISHER) |
| DOI | 10.1016/j.jep.2024.118882 |
| PMID | 39366497 |
| OpenAlex | W4403064269 |
| Language | EN |
| References cited | 49 |
Sophocarpine is a potential competitive inhibitor of TRPA1 and TRPV1 channels eliciting strong anti-inflammatory, anti-pruritic, and analgesic effects, suggesting its significant therapeutic potential in treating diseases with inflammatory itch and pain
Analgesic · Anti-inflammatory · Inflammation · Herbal Medicine Research Studies · Ion Channels and Receptors · Medicine · Pharmacological Effects of Natural Compounds · Immunology · Pharmacology
| Citation velocity | historical |
|---|---|
| Highly cited | No |