Integrated bioinformatics and multi-omics to investigate the mechanism of Rhododendron molle Flos-induced hepatotoxicity
Bibliographic Data
| ID | 14746387 |
|---|---|
| Authors | Qiang Ran (First People's Hospital of Chongqing), Mengjun Huang (0000-0002-3341-8011, Chongqing University), Lijuan Wang (0000-0002-2225-6483, First People's Hospital of Chongqing), Yanyan Li (0009-0000-0010-2654, First People's Hospital of Chongqing), Wenhui Wu (0000-0002-1465-0384, First People's Hospital of Chongqing), Xia Liu (0000-0003-1136-4742, First People's Hospital of Chongqing), Juan Chen (0000-0002-1038-4162, First People's Hospital of Chongqing), Min Yang (0000-0001-9017-5960, First People's Hospital of Chongqing), Keqing Han (0000-0002-8149-5249, Shanxi Medical University, corresponding author), Xiaohong Guo (0009-0002-6862-6301, First People's Hospital of Chongqing, corresponding author) |
| Year | 2025 |
| Volume | 341 |
| Pages | 119308 |
| Publication date | 2025-02-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Journal of Ethnopharmacology (JOURNAL) |
| Journal identifiers | ISSN: 0378-8741 • E-ISSN: 1872-7573 |
| Publisher | Elsevier BV (PUBLISHER) |
| DOI | 10.1016/j.jep.2024.119308 |
| PMID | 39746411 |
| OpenAlex | W4405931365 |
| Language | EN |
| Citations received | 1 |
| References cited | 57 |
This study comprehensively identified the toxic components, upstream targets, and downstream metabolites of RMF-induced liver toxicity, providing a basis for evaluating and monitoring liver function in patients during clinical application
Antioxidant · Bioinformatics · Biology · Flos · Mechanism (biology · Omics · Rutin · Traditional medicine · Computational Drug Discovery Methods · Drug-Induced Hepatotoxicity and Protection · Medicine · Metabolomics and Mass Spectrometry Studies · Biochemistry · Biotechnology
Exploring the pharmacological mechanisms of the flower of Rhododendron molle in rheumatoid arthritis rats based on metabolomics integrated network pharmacology
The integrated pharmacokinetics of major rhodojaponins correlates with the cardiotoxicity after oral administration of Rhododendri Mollis Flos extract in rats
Evaluation of Rhodojaponin III from Rhododendron molle G. Don on oral antinociceptive activity, mechanism of action, and subacute toxicity in rodents
Metabonomics and pharmacodynamics studies of Gentiana radix and wine-processed Gentiana radix in damp-heat jaundice syndrome rats
Analysis of grayanatoxin in Rhododendron honey and effect on antioxidant parameters in rats
The efficacy and toxicity of grayanoids as analgesics
| Unique citing works | 1 |
|---|---|
| Citations per year | 1 |
| Citation span | 2026 - 2026 (1) |
| Citation velocity | current |
| Highly cited | No |
| Citation types | Neutral: 1 |