Reinfection following successful direct-acting antiviral therapy for hepatitis C virus infection among people with recent injecting drug use

The SHARP-C study

Bibliographic Data

ID14908663
AuthorsJoshua Ang, Joshua Ping Ang (0000-0003-2521-3590, UNSW Sydney, corresponding author), Behzad Hajarizadeh (0000-0003-2212-2028, UNSW Sydney), Shane Tillakeratne (0000-0002-5988-3579, UNSW Sydney), Gregory J Dore (0000-0002-4741-2622, UNSW Sydney), Carla Treloar (0000-0002-8230-0386, UNSW Sydney), Janaki Amin (0000-0003-2161-9366, Macquarie University), Jodi Van Dyk (UNSW Sydney), Louisa Degenhardt (0000-0002-8513-2218, UNSW Sydney), Tanya Applegate (0000-0002-8657-4261, UNSW Sydney), Adrian J Dunlop (0000-0003-2394-5966, Hunter New England Local Health District), Adrian Dunlop, Chris Fraser (0000-0003-4611-6589), Brian Conway (0000-0001-6821-7829), Brian E Conway (Vancouver Infectious Diseases Centre), Alexander Wong (0009-0009-9781-5479, University of Regina), Dennaye Fuchs (Saskatchewan Health), Jeff Powis (0000-0003-2053-6083, Toronto East General Hospital), Kate Mason (0000-0001-5020-5256, Regent Park Community Health Centre), Edward J Gane, Edward Gane (0000-0003-4086-7955, University of Auckland), Michelle Weltman (0000-0002-1677-7653, Nepean Hospital), Martin Weltman, Phillip Read (0000-0001-5422-3777, South Eastern Sydney Local Health District), Marianne Martinello (0000-0001-9444-0186, Blacktown & Mount Druitt Hospital), Emily Rowe (0009-0000-6442-8792, Royal Adelaide Hospital), David G Baker (0000-0002-5507-0255), David A Baker, Alexandra Wade (Central Coast Local Health District), Gail Matthews (0000-0002-1048-6396, UNSW Sydney), Lise Lafferty (0000-0002-8533-2957, UNSW Sydney), Andrew Lloyd (0000-0002-7597-6556), Andrew R Lloyd (0000-0001-6277-8887, UNSW Sydney), J Grebely (0000-0002-1833-2017, UNSW Sydney), Evan B Cunningham (0000-0002-8048-3473, St Vincent's Clinic)
Year2025
Volume143
Pages104859
Publication date2025-09-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueInternational Journal of Drug Policy (JOURNAL)
Journal identifiersISSN: 0955-3959 • E-ISSN: 1873-4758
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.drugpo.2025.104859
PMID40554239
OpenAlexW4411406337
LanguageEN
Citations received1
References cited25

The relatively high incidence of reinfection seen in this study underscores the importance of targeted harm reduction measures and monitoring for HCV reinfections within the first year following successful treatment among people who inject drugs. Additional research into integrated models of care incorporating harm reduction and supporting reducing risk of reinfection and HCV treatment are needed

Antiviral therapy · Chronic hepatitis · Drug · Hepatitis C · Hepatitis C virus · Virus · Hepatitis B Virus Studies · Hepatitis C virus research · HIV, Drug Use, Sexual Risk · Medicine · Immunology · Pharmacology · Virology