Sociodemographic characteristics, clinical manifestations, and concurrent outcomes of Oropouche fever and dengue in Espírito Santo, Brazil

Bibliographic Data

ID14968109
AuthorsJoão Paulo Cola (0000-0003-4972-4686, Secretaria de Estado da Saúde do Espírito Santo, Espírito Santo, Brazil., corresponding author), Thiago Nascimento Do Prado (0000-0001-8132-6288, Universidade Federal do Espírito Santo, Espírito Santo, Brazil.), Otavio T Ranzani (0000-0002-4677-6862, DataHealth Lab, Institut de Recerca Sant Pau (IR SANT PAU), Barcelona, Spain.), Ana Paula Brioschi dos Santos (0000-0002-9701-0314, Secretaria de Estado da Saúde do Espírito Santo, Espírito Santo, Brazil.), Brenda Silva Freire (Universidade Federal do Espírito Santo, Espírito Santo, Brazil.), Raphael Lubiana Zanotti (0000-0002-8886-983X, Secretaria de Estado da Saúde do Espírito Santo, Espírito Santo, Brazil.), A Costa (0000-0002-9758-238X), Adriana Endlich da Silva Dela Costa (Secretaria de Estado da Saúde do Espírito Santo, Espírito Santo, Brazil.), Karina Bertazo Del Carro (0000-0002-9757-2595, Secretaria de Estado da Saúde do Espírito Santo, Espírito Santo, Brazil.), Lesliane de Amorim Lacerda Coelho (Secretaria de Estado da Saúde do Espírito Santo, Espírito Santo, Brazil.), Cíntia Lepaus Thomas (0009-0002-0649-8682, Universidade Federal do Espírito Santo, Espírito Santo, Brazil.), Dijoce Prates Bezerra (Secretaria de Estado da Saúde do Espírito Santo, Espírito Santo, Brazil.), Orlei Amaral Cardoso (0000-0002-0140-7078, Secretaria de Estado da Saúde do Espírito Santo, Espírito Santo, Brazil.), Angélica Espinosa Miranda (0000-0002-5556-8379, Universidade Federal do Espírito Santo, Espírito Santo, Brazil.), Ethel Leonor Noia Maciel (0000-0003-4826-3355, Universidade Federal do Espírito Santo, Espírito Santo, Brazil.), Creuza Rachel Vicente (0000-0003-0182-7969, Universidade Federal do Espírito Santo, Espírito Santo, Brazil.)
Year2025
Volume49
Pages1
Publication date2025-12-24
Open AccessYes
TypeARTICLE
VenueRevista Panamericana de Salud Pública (JOURNAL)
Journal identifiersISSN: 1020-4989 • E-ISSN: 1680-5348
PublisherPan American Health Organization (PUBLISHER • US)
DOI10.26633/rpsp.2025.127
PMID41450792
OpenAlexW7117141037
LanguageEN
References cited23

Objective. To compare sociodemographic and clinical characteristics and the outcome severity between confirmed cases of Oropouche fever and dengue in the state of Espírito Santo, Brazil. Methods. A cross-sectional study used secondary data from the state health surveillance system of Espírito Santo, 2024–2025. The study includes laboratory-confirmed cases of Oropouche fever and dengue. The authors calculated absolute and relative frequencies of variables. Pearson’s chi-square and Fisher’s exact tests assessed differences. Firth’s penalized logistic regression estimated odds ratios (OR) for severe manifestations and death, with 95% confidence intervals (95% CI). Results. A total of 12 135 OF cases and 18 018 dengue cases were confirmed. Compared with dengue cases, Oropouche fever was more prevalent among males (53.5%), white individuals (56.3%), and residents of rural and peri-urban areas (52.1%). Fever (84.5% vs. 78.7%), headache (83.9% vs. 72.1%), and myalgia (76.5% vs. 67.5%) were the most common symptoms in both groups, with significantly higher proportions among Oropouche fever cases. Dengue cases showed higher odds of progressing to severe disease (OR 15.35; 95% CI 10.60–22.23) and death (OR 2.09; 95% CI 1.10–3.98). Conclusion. Oropouche fever and dengue presented overlapping clinical profiles; however, Oropouche fever was more frequent in rural and peri-urban areas. Dengue was associated with greater severity and lethality. These findings underscore the importance of surveillance to support strategies for monitoring, clinical management, and control, while accounting for the distinct epidemiological and clinical profiles of Oropouche fever and dengue

Dengue fever · Epidemiological surveillance · Incidence (geometry · Rural area · Rural population · Mosquito-borne diseases and control · Viral Infections and Outbreaks Research · Zoonotic diseases and public health · Epidemiology

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