The burden of pneumococcal disease among Latin American and Caribbean children

Review of the evidence

Bibliographic Data

ID14968809
AuthorsMarina Tejonero Valenzuela (0000-0002-9433-6423, Universidad de Los Andes, Chile), María Teresa Valenzuela (0000-0002-1438-8187), Rosalyn O'Loughlin, Rosalyn O’Loughlin (Centers for Disease Control and Prevention), Fernando De La Hoz (0000-0001-9436-7935, Universidad Nacional de Colombia), Elizabeth Gómez (0000-0001-7301-4268), Elizabeth Avery Gomez (0000-0003-2698-3984, Secretaria de Salud), Dagna Constenla (0000-0003-4935-1584, Colorado State University), Anushua Sinha (Rutgers, the State University of New Jersey), J E Valencia (0009-0001-7016-8031, Clínica CES), Brendan Flannery (0000-0001-5041-308X, Centers for Disease Control and Prevention), Ciro A de Quadros (World Health Organization Regional Office for the Americas)
Year2009
Volume25
Issue3
Pages270-9
Publication date2009-03-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueRevista Panamericana de Salud Pública (JOURNAL)
Journal identifiersISSN: 1020-4989 • E-ISSN: 1680-5348
PublisherFapUNIFESP (SciELO) (PUBLISHER)
DOI10.1590/s1020-49892009000300011
PMID19454155
OpenAlexW2005136907
SCIELO_PIDS1020-49892009000300011
LanguageEN
Citations received9
References cited5

OBJECTIVE: To conduct a comprehensive review of data on pneumococcal disease incidence in Latin America and the Caribbean and project the annual number of pneumococcal disease episodes and deaths among children < 5 years of age in the region. METHODS: We carried out a systematic review (1990 to 2006) on the burden of pneumococcal disease in children < 5 years of age in the region. We summarized annual incidence rates and case fatality ratios using medians and interquartile ranges for invasive pneumococcal disease (IPD) (including all-IPD and separately abstracting pneumococcal meningitis, pneumonia, bacteremia, and sepsis data), pneumonia (all cause and radiologically confirmed), and acute otitis media by age group: < 1 year, < 2 years, and < 5 years. We modeled age-specific cumulative incidence of disease obtained from standard Kaplan-Meier analysis and projected data to obtain regional estimates of disease burden. We adjusted burden estimates by serotype coverage, vaccination coverage, and vaccine efficacy to estimate the number of cases and deaths averted. RESULTS: Of 5 998 citations identified, 26 papers from 10 countries were included. The estimated annual burden of pneumonia, meningitis, and acute otitis media caused by pneumococcus in children < 5 years of age ranged from 980 000 to 1 500 000, 2 600 to 6 800, and 980 000 to 1 500 000, respectively. An estimated 12 000 to 28 000 deaths due to pneumococcal disease occur in the region annually. Pneumococcal conjugate vaccine could save 1 life per 1 100 and prevent 1 case per 13 children vaccinated. CONCLUSION: A substantial burden of pneumococcal disease in the region is potentially preventable with pneumococcal conjugate vaccines and should be considered in regional vaccine decision making. Results are limited by the very few studies, conducted in selected settings, included in this review

Case fatality rate · Disease · Disease burden · Meningitis · Otitis · Pneumococcal conjugate vaccine · Pneumococcal infections · Pneumococcal pneumonia · Pneumonia · Streptococcus pneumoniae · Influenza Virus Research Studies · Medicine · Pneumonia and Respiratory Infections · Respiratory viral infections research · Epidemiology · Internal Medicine · Pediatrics · Surgery

Tools

Open DOIOpen Access