Gestion des déchets
Question d'institutions démocratiques ou question d'industrialisation
Bibliographic Data
| ID | 15049413 |
|---|---|
| Authors | René Devos (Laboratoire Bourguignon des Matériaux et Procédés, corresponding author) |
| Year | 1998 |
| Volume | 6 |
| Issue | 3 |
| Pages | 48-54 |
| Publication date | 1998-09-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Natures Sciences Sociétés (JOURNAL) |
| Journal identifiers | ISSN: 1240-1307 • E-ISSN: 1765-2979 |
| Publisher | Elsevier BV (PUBLISHER) |
| DOI | 10.1016/s1240-1307(98)80086-1 |
| OpenAlex | W1918446142 |
| Language | FR |
| References cited | 2 |
To develop a more effective and safer drug for the treatment of type 2 diabetes mellitus (T2DM)-induced liver damage, we investigated the protective effects of punicalagin, a major component in pomegranate peel, on the liver of mice with T2DM. After five weeks of punicalagin treatment, blood and liver samples were obtained for the subsequent analyses. Western blotting, reverse transcription polymerase chain reaction, and immunohistochemical staining were performed to determine the expression of endoplasmic reticulum (ER) stress markers in the liver tissue. The results showed that punicalagin alleviated glucose and insulin resistance, increased insulin sensitivity, and reduced serum free fatty acids levels and hepatic steatosis in the mice with T2DM. Furthermore, punicalagin down-regulated the elevated mRNA expression of the ER stress markers eIF2α, GRP78, ATF4, and CHOP in the liver of mice with T2DM. Our results suggest that punicalagin is a potential natural agent for the prevention of T2DM-induced liver damage
Biology · CHOP · Diabetes mellitus · Endoplasmic reticulum · Gene · Insulin · Insulin resistance · Messenger RNA · Reverse transcription polymerase chain reaction · Steatosis · Type 2 Diabetes Mellitus · Unfolded protein response · French Urban and Social Studies · Medicine · Biochemistry · Endocrinology · Internal Medicine
| Highly cited | No |
|---|