Body size over the adult life course and the risk of colorectal cancer among postmenopausal women
Bibliographic Data
| ID | 15090159 |
|---|---|
| Authors | Le Su (0000-0003-2810-1703, Indiana University Bloomington, corresponding author), Michael Hendryx (0000-0002-2764-387X, Indiana University Bloomington), Ming Li (0000-0001-7109-5084, Indiana University Bloomington), Aladdin H Shadyab (0000-0002-9693-0522, University of California San Diego), Nazmus Saquib (0000-0002-2819-2839, Sulaiman Al Rajhi Colleges), Marcia L Stefanick (0000-0002-0284-6996, Stanford University), Juhua Luo (0000-0002-8901-4462, Indiana University Bloomington) |
| Year | 2023 |
| Volume | 26 |
| Issue | 8 |
| Pages | 1539-1548 |
| Publication date | 2023-08-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Public Health Nutrition (JOURNAL) |
| Journal identifiers | ISSN: 1368-9800 • E-ISSN: 1475-2727 |
| Publisher | Cambridge University Press (CUP) (PUBLISHER) |
| DOI | 10.1017/s1368980023000988 |
| PMID | 37199248 |
| OpenAlex | W4377011654 |
| Language | EN |
| Citations received | 1 |
| References cited | 39 |
Objective: To assess the associations among several anthropometric measures, as well as BMI trajectories and colorectal cancer (CRC) risk in older women. Design: Prospective cohort study. Setting: Forty clinical centres in the USA. Participants: Totally, 79 034 postmenopausal women in the Women’s Health Initiative Observational Study. Results: During an average of 15·8 years of follow-up, 1514 CRC cases were ascertained. Five BMI trajectories over 18–50 years of age were identified using growth mixture model. Compared with women who had a normal BMI at age 18, women with obesity at age 18 had a higher risk of CRC (HR 1·58, 95 % CI 1·02, 2·44). Compared with women who kept relatively low normal body size during adulthood, women who progressed from normal to obesity (HR 1·29, 95 % CI 1·09, 1·53) and women who progressed from overweight to obesity (HR 1·37, 95 % CI 1·13, 1·68) had higher CRC risks. A weight gain > 15 kg from age 18 to 50 (HR 1·20, 95 % CI 1·04, 1·40) and baseline waist circumference > 88 cm (HR 1·33, 95 % CI 1·19, 1·49) were associated with higher CRC risks, compared with stable weight and waist circumference ≤ 88 cm, respectively. Conclusion: Women who have a normal weight in early adult life and gain substantial weight later, as well as those who are persistently heavy over adulthood, demonstrated a higher risk of developing CRC. Our study highlights the importance of maintaining a healthy body weight over the life course for reducing the risk of developing CRC in women
Anthropometry · Body mass index · Body weight · Breast cancer · Cancer · Cohort study · Colorectal cancer · Life course approach · Obesity · Obstetrics · Overweight · Postmenopausal women · Prospective cohort study · Waist · Weight change · Weight gain · Weight loss · Women's Health Initiative · Cancer Risks and Factors · Colorectal Cancer Screening and Detection · Demography · Genetic factors in colorectal cancer · Medicine · Psychology · Internal Medicine
| Citations per year | 0.5 |
|---|---|
| Citation span | 2024 - 2024 (1) |
| Highly cited | No |