Association between low levels of 1,25-dihydroxyvitamin D and breast cancer risk
Bibliographic Data
| ID | 15090666 |
|---|---|
| Authors | Esther C Janowsky (University of North Carolina Health Care, corresponding author), Gayle E Lester (University of North Carolina at Chapel Hill), Clarice R Weinberg (0000-0002-7713-8556, Triangle), Robert C Millikan (University of North Carolina at Chapel Hill), Joellen M Schildkraut (0000-0002-0990-9339, Duke Medical Center), Peter A Garrett (University of North Carolina at Chapel Hill), Barbara S Hulka (University of North Carolina at Chapel Hill) |
| Year | 1999 |
| Volume | 2 |
| Issue | 3 |
| Pages | 283-291 |
| Publication date | 1999-03-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Public Health Nutrition (JOURNAL) |
| Journal identifiers | ISSN: 1368-9800 • E-ISSN: 1475-2727 |
| Publisher | Cambridge University Press (CUP) (PUBLISHER) |
| DOI | 10.1017/s1368980099000385 |
| PMID | 10512563 |
| OpenAlex | W2116444950 |
| Language | EN |
| Citations received | 2 |
| References cited | 37 |
Objective To determine if blood levels of 25-hydroxyvitamin D (25-D) or its active metabolite, 1,25-dihydroxyvitamin D (1,25-D), are lower in women at the time of first diagnosis of breast cancer than in comparable women without breast cancer. Design This was a clinic-based case–control study with controls frequency-matched to cases on race, age, clinic and month of blood drawing. Setting University-based breast referral clinics. Subjects One hundred and fifty-six women with histologically documented adenocarcinoma of the breast and 184 breast clinic controls. Results There were significant mean differences in 1,25-D levels (pmol ml −1 ) between breast cancer cases and controls; white cases had lower 1,25-D levels than white controls (mean difference ± SE: −11.08 ± 0.76), and black cases had higher 1,25-D levels than black controls (mean difference ± SE: 4.54 ± 2.14), although the number of black women in the study was small. After adjustment for age, assay batch, month of blood draw, clinic and sample storage time, the odds ratio (95% confidence interval, CI) for lowest relative to highest quartile was 5.2 (95% CI 2.1, 12.8) for white cases and controls. The association in white women was stronger in women above the median age of 54 than in younger women, 4.7 (95% CI 2.1, 10.2) vs. 1.5 (95% CI 0.7, 3.0). There were no case–control differences in 25-D levels in either group. Conclusions These data are consistent with a protective effect of 1,25-D for breast cancer in white women
Breast cancer · Cancer · Case-control study · Confidence interval · Gynecology · Odds ratio · Quartile · Referral · Cancer Risks and Factors · Estrogen and related hormone effects · Medicine · Vitamin D Research Studies · Internal Medicine
| Citations per year | 0.1 |
|---|---|
| Citation span | 2006 - 2012 (7) |
| Highly cited | No |