Leaf concentrate as an alternative to iron and folic acid supplements for anaemic adolescent girls
A randomised controlled trial in India
Bibliographic Data
| ID | 15091082 |
|---|---|
| Authors | Swati Vyas (0000-0002-5923-2274, Inspiration Innovation Synergy University), Simon M Collin (0000-0002-1239-1681, University of Bristol, corresponding author), Éric Bertin (0000-0002-7354-6755, Université de Reims Champagne-Ardenne), Glyn J Davys, Beena Mathur, B N Mathur (University of Rajasthan) |
| Year | 2010 |
| Volume | 13 |
| Issue | 3 |
| Pages | 418-423 |
| Publication date | 2010-03-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Public Health Nutrition (JOURNAL) |
| Journal identifiers | ISSN: 1368-9800 • E-ISSN: 1475-2727 |
| Publisher | Cambridge University Press (CUP) (PUBLISHER) |
| DOI | 10.1017/s1368980009991224 |
| PMID | 19706212 |
| OpenAlex | W2169183859 |
| Language | EN |
| Citations received | 4 |
| References cited | 22 |
Objective Despite public health campaigns based on Fe and folic acid supplements, Fe-deficiency anaemia remains highly prevalent among women in India. We investigated leaf concentrate as an alternative to Fe and folic acid supplements for treating anaemia in adolescent girls. Design Randomised controlled two-arm trial over 3 months: one group received daily Fe and folic acid (IFA; 60 mg Fe, 500 μg folic acid); the other daily leaf concentrate (LC; 5 mg Fe, 13 μg folic acid). Hb concentration, mean cell volume, serum Fe, serum ferritin and total Fe-binding capacity were measured pre- and post-intervention. Setting Jaipur, India. Subjects One hundred and two adolescent girls aged 14–18 years. Results Of the 102 girls randomized to the two arms of the trial, four (3·9 %) were severely anaemic (Hb P = 0·005). Total losses to follow-up were 14/54 in the IFA group and 2/48 in the LC group. At the end of the trial, none of the eighty-six remaining girls were severely anaemic, nine (10·5 %) were moderately anaemic and twenty-six (30·2 %) were mildly anaemic; fifty-one (59·3 %) had normal Hb levels (≥12 g/dl). After adjustment for baseline values, LC was as effective as IFA in improving serum Fe parameters and treating anaemia. Conclusions Leaf concentrate is an effective, and more palatable, alternative to Fe and folic acid supplements for treating anaemia in adolescent girls
Anemia · Biology · folic acid · Folic acid supplementation · Girl · Iron deficiency · Randomized controlled trial · Traditional medicine · Child Nutrition and Water Access · Hemoglobinopathies and Related Disorders · Iron Metabolism and Disorders · Medicine · Gastroenterology · Internal Medicine · Pediatrics
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| Citations per year | 0.25 |
|---|---|
| Citation span | 2010 - 2016 (7) |
| Highly cited | No |