Vitamin D insufficiency/deficiency is associated with insulin resistance in Brazilian children, regardless of body fat distribution

Dados Bibliográficos

ID15091084
AutoresLuana Cupertino Milagres (0000-0002-3186-7577, Universidade Federal de Viçosa, autor correspondente), Naruna Pereira Rocha (0000-0001-7513-3906, Universidade Federal de Viçosa), Mariana De Santis Filgueiras (0000-0003-1932-6126, Universidade Federal de Viçosa), Fernanda Martins De Albuquerque (0000-0003-1675-5232, Universidade Federal de Viçosa), Ana Paula Pereira Castro (0000-0002-0017-6626, Universidade Federal de Viçosa), Milene Cristine Pessoa (0000-0002-1053-5450, Universidade Federal de Minas Gerais), Maria Do C G Peluzio (0000-0003-4665-7043, Universidade Federal de Viçosa), Juliana Farias De Novaes (0000-0003-1363-323X), Juliana Farias Novaes (0000-0003-3616-5096, Universidade Federal de Viçosa)
Ano2017
Volume20
Fascículo16
Páginas2878-2886
Data de publicação2017-11-01
Peer ReviewedSim
Open AccessSim
TipoARTICLE
PeriódicoPublic Health Nutrition (JOURNAL)
Identificadores do periódicoISSN: 1368-9800 • E-ISSN: 1475-2727
EditoraCambridge University Press (CUP) (PUBLISHER)
DOI10.1017/s136898001700194x
PMID28829285
OpenAlexW2745567391
IdiomaEN
Citações recebidas5
Referências citadas46

Objective To assess the prevalence of vitamin D insufficiency and deficiency and its association with cardiometabolic risk factors, controlled by adiposity, in a representative sample of prepubescent children. Design Cross-sectional population-based study. Body composition was evaluated by dual-energy X-ray absorptiometry. Anthropometric measures and blood pressure were performed. Laboratory analyses were performed to determine the levels of vitamin D (25-hydroxyitamin D; 25(OH)D), glucose, insulin, serum lipids and intact parathyroid hormone. Dietary intake was assessed by three 24 h recalls. Setting Viçosa, Minas Gerais, Brazil, 2015. Subjects Representative sample of 378 children aged 8 and 9 years from urban schools. Results Inadequate serum concentrations of 25(OH)D were diagnosed in more than half of the children and none of them met the recommended vitamin D intake. After adjusting for confounding factors in the multiple regression analysis, lower prevalence of insulin resistance and hypertriacylglycerolaemia was found in children with serum 25(OH)D levels ≥75 nmol/l (prevalence ratio=0·25; 95 % CI 0·08, 0·85) and ≥50 nmol/l (prevalence ratio=0·61; 95 % CI 0·37, 0·99), respectively. However, after adjusting for different indicators of adiposity, insulin resistance remained independently associated and the association with hypertriacylglycerolaemia was lost after adjusting for central adiposity. The prevalence of vitamin D insufficiency/deficiency was associated with the number of cardiometabolic alterations in children. Conclusions The study results showed that prevalence of vitamin D insufficiency/deficiency was high among the children and insulin resistance was the main cardiometabolic alteration associated with this condition, even in a tropical climate country such as Brazil

Anthropometry · Calcium · Confounding · Cross-sectional study · Environmental health · Insulin · Insulin resistance · Parathyroid hormone · Population · Vitamin · Vitamin D and neurology · vitamin D deficiency · Medicine · Nutritional Studies and Diet · Obesity, Physical Activity, Diet · Vitamin D Research Studies · Endocrinology · Internal Medicine