The aetiology of anaemia during pregnancy
A study to evaluate the contribution of iron deficiency and common infections in pregnant Ugandan women
Bibliographic Data
| ID | 15092161 |
|---|---|
| Authors | Rhona Baingana (0000-0002-9954-8257, corresponding author), Rhona K Baingana, John Kiboko Enyaru, Harold Tjalsma (Radboud University Nijmegen), Dorine W Swinkels (0000-0002-1040-9446, Radboud University Medical Center), Lena Davidsson (0000-0001-9322-5513) |
| Year | 2015 |
| Volume | 18 |
| Issue | 8 |
| Pages | 1423-1435 |
| Publication date | 2015-06-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Public Health Nutrition (JOURNAL) |
| Journal identifiers | ISSN: 1368-9800 • E-ISSN: 1475-2727 |
| Publisher | Cambridge University Press (CUP) (PUBLISHER) |
| DOI | 10.1017/s1368980014001888 |
| PMID | 25222882 |
| OpenAlex | W2099552740 |
| Language | EN |
| Citations received | 1 |
| References cited | 56 |
Objective To describe the aetiology of anaemia in pregnant Ugandan women and explore Fe deficiency and common infections as contributors to anaemia in this population. Design Cross-sectional study in which Hb, ferritin, transferrin receptor (sTfR), C-reactive protein, α-1 acid glycoprotein, hepcidin, malaria, hookworm infestation, syphilis and Helicobacter pylori infection were assessed. Setting Antenatal care clinic at Kawempe Health Centre, Kampala, Uganda. Subjects HIV-negative women ( n 151) in their first or second pregnancy at 10–16 weeks’ gestation. Results The prevalence of anaemia was 29·1 %. Fe deficiency was 40·4 % and 14·6 % based on ferritin 8·3 μg/ml. The prevalence of Fe-deficiency anaemia was 9·3 % based on ferritin 8·3 μg/ml. Hepcidin concentration was positively correlated with ferritin concentration ( n 151, r =0·578, P H. pylori infection was highly prevalent (70 %) while malaria, hookworm infestation and syphilis were not common. Of all women, 60·3 % had α-1 acid glycoprotein >1 g/l and/or C-reactive protein >5 mg/l. Malaria parasitaemia (OR=6·85; 95 % CI 1·25, 37·41, P= 0·026) and Fe deficiency defined using sTfR (OR=5·58; 95 % CI 1·26, 24·80, P= 0·024) were independently and positively associated with anaemia. Population-attributable risk factors for anaemia for raised C-reactive protein, Fe deficiency defined by sTfR >8·3 μg/ml and presence of malaria parasites were 41·6 (95 % CI 11·1, 72·2) %, 13·5 (95 % CI 2·0, 25·0) % and 12·0 (95 % CI 1·4, 22·6) %, respectively. Conclusions Infections and inflammation are of greater significance than Fe deficiency in the aetiology of anaemia in pregnant Ugandan women during the first trimester
Anemia · Biology · Ferritin · Iron deficiency · Iron status · Malaria · Obstetrics · Population · Pregnancy · Soluble transferrin receptor · Child Nutrition and Water Access · Hemoglobinopathies and Related Disorders · Iron Metabolism and Disorders · Medicine · Gastroenterology · Immunology · Internal Medicine
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| Unique citing works | 1 |
|---|---|
| Citations per year | 0,25 |
| Citation span | 2022 - 2022 (1) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 1 |