Maternal carbohydrate intake during pregnancy is associated with child peripubertal markers of metabolic health but not adiposity

Bibliographic Data

ID15092269
AuthorsMolly C Mulcahy (0000-0002-8903-7357, University of Michigan), Martha Maria Téllez-Rojo, Martha María Téllez‐Rojo (0000-0003-3322-3334, Instituto Nacional de Salud Pública), Alejandra Cantoral (0000-0002-1397-8476, Ibero American University, corresponding author), Maritsa Solano-González (Instituto Nacional de Salud Pública), Ana Baylin (0000-0002-6602-0392, University of Michigan), Dave Bridges (0000-0002-5334-972X, University of Michigan), Karen E Peterson (0000-0003-0471-1427, University of Michigan), Wei Perng (0000-0001-8552-6850, Colorado School of Public Health)
Year2022
Volume25
Issue9
Pages2541-2553
Publication date2022-09-01
Open AccessYes
TypeARTICLE
VenuePublic Health Nutrition (JOURNAL)
Journal identifiersISSN: 1368-9800 • E-ISSN: 1475-2727
PublisherCambridge University Press (CUP) (PUBLISHER)
DOI10.1017/s1368980021004614
PMID34814962
OpenAlexW3217614926
LanguageEN
References cited51

Objective: To examine the associations of trimester-specific maternal prenatal carbohydrate (CHO) intake with offspring adiposity and metabolic health during peripuberty. Design: Prospective cohort study in which maternal dietary intake was collected via validated FFQ during each trimester. Offspring adiposity and metabolic biomarkers were evaluated at age 8–14 years. We used multivariable linear regression to examine associations between total energy-adjusted maternal CHO intake and offspring BMI z -score, skinfold thickness and metabolic syndrome risk z -score calculated as the average of waist circumference, fasting glucose, fasting C-peptide, TAG:HDL and systolic blood pressure + diastolic blood pressure/2. Setting: Mexico City, Mexico Participants: 237 mother–child pairs in the Early Life Exposure in Mexico to Environmental Toxicants cohort. Results: We found non-linear associations of maternal CHO intake during pregnancy with offspring metabolic health during peripuberty. After adjusting for maternal age, and child age, sex and pubertal status, children whose mothers were in the fourth v . first quartile of total CHO intake during the third trimester had 0·42 (95 % CI –0·01, 0·08) ng/ml lower C-peptide and 0·10 (95 % CI –0·02, 0·22) units lower C-peptide insulin resistance (CP-IR). We found similar magnitude and direction of association with respect to net CHO intake during the first trimester and offspring C-peptide and CP-IR. Maternal CHO intake during pregnancy was not associated with offspring adiposity. Conclusions: In this study of mother–child pairs in Mexico City, children born to women in the highest quartile of CHO intake during pregnancy had lowest C-peptide and CP-IR during peripuberty. Additional research is warranted to replicate and identify mechanisms

Biology · Body mass index · Cohort · Confidence interval · Diabetes mellitus · Insulin resistance · Metabolic syndrome · Obstetrics · Offspring · Pregnancy · Prospective cohort study · Quartile · Waist · Birth, Development, and Health · Diet and metabolism studies · Medicine · Obesity, Physical Activity, Diet · Endocrinology · Internal Medicine · Physiology

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