Interaction between a refined carbohydrate dietary pattern and genetic risk score for obesity in the Korean population

Objective: Genetic predisposition to obesity can stimulate an increase in adiposity throughout adulthood. However, the interaction between genetic factors and dietary habits may modify the genetic association with obesity. Thus, this study aimed to investigate the dietary patterns that influence the genetic risk of obesity in a Korean population using a large cohort study and genome-wide association study. Design: Prospective cohort study. Setting: The genetic risk score (GRS) was calculated based on six identified SNP of the OTOL1 , NMBR , DNAJB9 , ASCC1 , NT5C2 and FTO genes associated with obesity, as ascertained by BMI. Dietary patterns were determined using food intake data from an FFQ and factor analysis. Participants: This study included data from 8458 adults aged 40–69 years from the Ansan and Ansung cohorts of the Korean Genome and Epidemiology Study. Results: The refined carbohydrate dietary pattern showed a significant inverse association with obesity in the highest GRS group with a non-significant interactive association (OR: 0·801; 95 % CI: 0·662, 0·969; P for trend = 0·0251, P for interaction = 0·571). However, participants with the highest refined carbohydrate dietary pattern score and highest GRS had an increased prevalence of obesity (OR: 1·288; 95 % CI: 1·068, 1·554; P for trend = 0·0251) compared with the prevalence of those with the lowest dietary pattern score and GRS. Conclusions: Reducing refined carbohydrate consumption may be helpful for Korean adults with a greater genetic susceptibility to obesity

Carbohydrate · Consumption (sociology · Genetic predisposition · Genetic variants · Korean population · Obesity · Population · Genetic Associations and Epidemiology · Nutrition, Genetics, and Disease · Nutritional Studies and Diet