Appetite testing in HIV-infected African adults recovering from malnutrition and given antiretroviral therapy
Bibliographic Data
| ID | 15094842 |
|---|---|
| Authors | Andrea M Rehman (0000-0001-9967-5822, London School of Hygiene & Tropical Medicine), Susannah Woodd (0000-0001-7389-2351, University of London), Molly Chisenga (0000-0003-0298-2397, University Teaching Hospital), Joshua Siame (University Teaching Hospital), Gemma Sampson (0000-0002-6194-5740, London School of Hygiene & Tropical Medicine), George Praygod (0000-0002-0329-4839, National Institute for Medical Research), John R Koethe (0000-0001-6490-6942, Vanderbilt University), Paul Kelly (0000-0003-1946-9848, University Teaching Hospital), Suzanne Filteau (0000-0002-1119-6825, London School of Hygiene & Tropical Medicine, corresponding author) |
| Year | 2015 |
| Volume | 18 |
| Issue | 4 |
| Pages | 742-751 |
| Publication date | 2015-03-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Public Health Nutrition (JOURNAL) |
| Journal identifiers | ISSN: 1368-9800 • E-ISSN: 1475-2727 |
| Publisher | Cambridge University Press (CUP) (PUBLISHER) |
| DOI | 10.1017/s1368980014000718 |
| PMID | 24785906 |
| OpenAlex | W2160823646 |
| Language | EN |
| Citations received | 3 |
| References cited | 20 |
Objective The Nutritional Support for Africans Starting Antiretroviral Therapy (NUSTART) trial was designed to determine whether nutritional support for malnourished HIV-infected adults starting antiretroviral therapy (ART) can improve early survival. Appetite is related to health outcomes in this population, but the optimal appetite metric for field use is uncertain. We evaluated two measures of appetite with the goal of improving understanding and treatment of malnutrition in HIV-infected adults. Design Longitudinal cohort study embedded in a clinical trial of vitamin and mineral-fortified, v . unfortified, lipid-based nutritional supplements. Setting HIV clinics in Mwanza, Tanzania and Lusaka, Zambia. Subjects Malnourished (BMI 2 ) HIV-infected adults starting ART. Results Appetite measurements, by short questionnaire and by weight of maize porridge consumed in a standardized test, were compared across time and correlated with changes in weight. Appetite questionnaire scores, from polychoric correlation, and porridge test results were normally distributed for Tanzanians ( n 187) but clustered and unreliable for Zambians ( n 297). Among Tanzanian patients, the appetite score increased rapidly from referral for ART, plateaued at the start of ART and then increased slowly during the 12-week follow-up. Change in appetite questionnaire score, but not porridge test, correlated with weight change in the corresponding two-week intervals ( P =0·002) or over the whole study ( P =0·05) but a point estimate of hunger did not predict weight change ( P =0·4). Conclusions In Tanzania change in appetite score correlated with weight change, but single point measurements did not. Appetite increases several weeks after the start of ART, which may be an appropriate time for nutritional interventions for malnourished HIV-infected adults
Appetite · Body mass index · Environmental health · Malnutrition · Obesity · Overweight · Population · Underweight · Weight change · Weight loss · Child Nutrition and Water Access · HIV-related health complications and treatments · HIV/AIDS Research and Interventions · Medicine · Gerontology · Internal Medicine · Pediatrics
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| Citations per year | 0.33 |
|---|---|
| Citation span | 2017 - 2021 (5) |
| Highly cited | No |