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The role of vitamins in the prevention and control of anaemia

Dados Bibliográficos

ID15095048
AutoresSteven M Fishman, Steven Fishman (Johns Hopkins University), Polly Christian (0000-0002-2908-1030, Johns Hopkins University, autor correspondente), Parul Christian, Keith P West (0000-0001-9458-362X, Johns Hopkins University)
Ano2000
Volume3
Fascículo2
Páginas125-150
Data de publicação2000-06-01
Peer ReviewedSim
Open AccessSim
TipoARTICLE
PeriódicoPublic Health Nutrition (JOURNAL)
Identificadores do periódicoISSN: 1368-9800 • E-ISSN: 1475-2727
EditoraCambridge University Press (CUP) (PUBLISHER)
DOI10.1017/s1368980000000173
PMID10948381
OpenAlexW2113885080
IdiomaEN
Citações recebidas24
Referências citadas110

Objective While iron deficiency is regarded as the major cause of nutritional anaemia, changes in vitamins A, B 12 , C and E, folic acid and riboflavin status have also been linked to its development and control. This paper provides a systematic review of vitamin supplementation trials relating to the control of nutritional anaemia. Methods A MEDLINE search was used to find reports of vitamin supplementation trials that reported changes in anaemia or iron status. Results Vitamin A can improve haematological indicators and enhance the efficacy of iron supplementation. Both folate and vitamin B 12 can cure and prevent megaloblastic anaemia. Riboflavin enhances the haematological response to iron, and its deficiency may account for a significant proportion of anaemia in many populations. Vitamin C enhances the absorption of dietary iron, although population-based data showing its efficacy in reducing anaemia or iron deficiency are lacking. Vitamin E supplementation given to preterm infants has not reduced the severity of the anaemia of prematurity. Vitamin B 6 effectively treats sideroblastic anaemia. Multivitamin supplementation may raise haemoglobin (Hb) concentration, but few studies have isolated the effect of multivitamins from iron on haematological status. Conclusions In general, the public health impact of vitamin supplementation in controlling anaemia is not clear. Neither are the complex interactions involving multiple vitamins in haematopoiesis sufficiently understood to explain the observed variability in haematological responses to vitamins by age, population, vitamin mixture and dosages. Further research is needed to understand the roles of individual and combined vitamin deficiencies on anaemia to design appropriate micronutrient interventions to prevent anaemia

Anemia · Biology · Dietary Reference Intake · Environmental health · Iron deficiency · Malnutrition · Micronutrient · Multivitamin · Population · Riboflavin · Vitamin · Vitamin B12 · Folate and B Vitamins Research · Iron Metabolism and Disorders · Medicine · Vitamin K Research Studies · Food Science · Internal Medicine · Physiology

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Obras citantes distintas24
Citações por ano1,5
Intervalo de citações2010 - 2026 (17)
Velocidade de citaçãocurrent
Altamente citadoNão
Tipos de citaçãoNeutras: 20
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