Preconception Hb concentration with risk of spontaneous abortion

A population-based cohort study in over 3·9 million women across rural China

Bibliographic Data

ID15095263
AuthorsQin Xu (0009-0004-5916-9828, National Health and Family Planning Commission), Ying Yang (0000-0002-3751-2590, Peking Union Medical College Hospital, corresponding author), Fangchao Liu (0000-0001-6316-4481, Chinese Academy of Medical Sciences & Peking Union Medical College), Long Wang (0000-0001-5600-8157, Lanzhou University), Qiaomei Wang (0000-0002-0757-5208, National Health and Family Planning Commission), Haiping Shen (0000-0001-5703-9975, National Health and Family Planning Commission), Zongyu Xu (National Health and Family Planning Commission), Yiping Zhang (0000-0002-8888-1345, Peking Union Medical College Hospital), Donghai Yan (National Health and Family Planning Commission), Yuan He (0000-0002-2981-2649, Chinese Academy of Medical Sciences & Peking Union Medical College), Ya Zhang (0000-0002-9717-911X, Chinese Academy of Medical Sciences & Peking Union Medical College), Hongguang Zhang (0000-0002-3179-5884, Chinese Academy of Medical Sciences & Peking Union Medical College), Zuoqi Peng (Chinese Academy of Medical Sciences & Peking Union Medical College), Xu Ma (0000-0001-7674-3589, Peking Union Medical College Hospital, corresponding author)
Year2020
Volume23
Issue16
Pages2963-2972
Publication date2020-11-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenuePublic Health Nutrition (JOURNAL)
Journal identifiersISSN: 1368-9800 • E-ISSN: 1475-2727
PublisherCambridge University Press (CUP) (PUBLISHER)
DOI10.1017/s1368980019003811
OpenAlexW3009831524
LanguageEN
Citations received2
References cited40

Objective: Evidence on the relationship between maternal Hb concentration and spontaneous abortion (SA) risk is limited and conflicting. The purpose of the study was to evaluate whether maternal preconception anaemia or high Hb concentration is associated with risk of SA. Design: A population-based cohort study established between 2013 and 2017. Settings: Local maternal and child care service centres in each county. Participants: In total, 3 971 428 women aged 20–49 years, who participated in National Free Pre-Pregnancy Checkups Project from 2013 to 2016 and successfully got pregnant before 2017 in rural China. Results: A total of 101 700 (2·56 %) women were recorded having SA, with highest SA rate in women with severe anaemia (4·58 %). Compared with women with Hb of 110–149 g/l, the multivariable-adjusted OR for SA was 1·52 (95 % CI: 1·25, 1·86) for women with Hb P non-linear Conclusions: Severe anaemia and high Hb concentration before pregnancy were associated with an increased risk of SA. Women with mild anaemia prior to pregnancy had lower risk of SA. Underlying mechanisms need to be further studied

Abortion · Cohort · Cohort study · Environmental health · Gynecology · Obstetrics · Population · Pregnancy · Demography · Gestational Diabetes Research and Management · Hemoglobinopathies and Related Disorders · Medicine · Pregnancy and preeclampsia studies · Internal Medicine

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