Association of dietary intake of branched-chain amino acids with long-term risks of CVD, cancer and all-cause mortality
Bibliographic Data
| ID | 15095773 |
|---|---|
| Authors | Binbin Xu (0000-0003-2035-6808, University of Chinese Academy of Sciences), Meng Wang (0000-0001-5799-549X, University of Chinese Academy of Sciences), Liyuan Pu (0000-0002-2874-4613, University of Chinese Academy of Sciences), Chang Shu (0000-0002-7880-9681, Tianjin Huanhu Hospital), Lian Li (0000-0002-1148-8289, University of Chinese Academy of Sciences, corresponding author), Liyuan Han (0000-0001-9766-9015, University of Chinese Academy of Sciences, corresponding author) |
| Year | 2022 |
| Volume | 25 |
| Issue | 12 |
| Pages | 3390-3400 |
| Publication date | 2022-12-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Public Health Nutrition (JOURNAL) |
| Journal identifiers | ISSN: 1368-9800 • E-ISSN: 1475-2727 |
| Publisher | Cambridge University Press (CUP) (PUBLISHER) |
| DOI | 10.1017/s1368980021004948 |
| PMID | 34930509 |
| OpenAlex | W4200101470 |
| Language | EN |
| References cited | 26 |
Objectives: We aimed to investigate the associations between dietary branched-chain amino acids (BCAA) intake and long-term risks of CVD, cancer and all-cause mortality in nationwide survey participants aged ≥ 18. Design: This was a prospective cohort study. Dietary intakes of BCAA (leucine, isoleucine and valine) were determined from the total nutrient intake document. The main outcomes were CVD, cancer and all-cause mortality. Setting: A nationally representative sample of US adults were recruited by the National Center for Health Statistics (NCHS) from 1988 to 1994. Participants: A total of 14 397 adults aged ≥ 18 who participated in the United States National Health and Nutrition Examination Survey III (NHANES III) were included. Results: During 289 406 person-years of follow-up, we identified 4219 deaths, including 1133 from CVD and 926 from cancer. After multivariate adjustment, the hazard ratios (95 % confidence intervals) of all-cause mortality in the highest dietary BCAA and isoleucine intake quintile (reference: lowest quintiles) were 0·68 (0·48, 0·97) and 0·68 (0·48, 0·97), respectively. Each one-standard-deviation increase in total dietary BCAA or isoleucine intake was associated with an 18 % or 21 % decrease in the risk of all-cause mortality, respectively. The serum triglyceride (TAG) concentration was found to modify the association between the dietary BCAA intake and all-cause mortality ( P for interaction = 0·008). Conclusions: In a nationally representative cohort, higher dietary intakes of BCAA and isoleucine were independently associated with a lower risk of all-cause mortality, and these associations were stronger in participants with higher serum TAG concentrations
Cohort · Cohort study · Confidence interval · Environmental health · Hazard ratio · National Health and Nutrition Examination Survey · Population · Prospective cohort study · Demography · Medicine · Muscle metabolism and nutrition · Nutrition and Health in Aging · Nutritional Studies and Diet · Internal Medicine
| Highly cited | No |
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