Vitamin E and risk of age-related cataract
A meta-analysis
Bibliographic Data
| ID | 15096006 |
|---|---|
| Authors | Yufei Zhang (0009-0002-6560-8204), Wenjie Jiang (0000-0002-3963-0857), Zhutian Xie, Wenlong Wu (0009-0006-3541-781X), Dongfeng Zhang (0000-0001-9308-9371) |
| Year | 2015 |
| Volume | 18 |
| Issue | 15 |
| Pages | 2804-2814 |
| Publication date | 2015-10-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Public Health Nutrition (JOURNAL) |
| Journal identifiers | ISSN: 1368-9800 • E-ISSN: 1475-2727 |
| Publisher | Cambridge University Press (CUP) (PUBLISHER) |
| DOI | 10.1017/s1368980014003115 |
| PMID | 25591715 |
| Language | EN |
| Citations received | 1 |
| References cited | 60 |
Objective We conducted a meta-analysis to evaluate the relationship between vitamin E and age-related cataract (ARC). Design The fixed- or random-effect model was selected based on heterogeneity. Meta-regression was used to explore potential sources of between-study heterogeneity. Publication bias was evaluated using Begg’s test. The dose–response relationship was assessed by a restricted cubic spline model. Setting Relevant studies were identified by a search of PubMed and the Cochrane Library to May 2014, without language restrictions. Subjects Studies involved samples of people of all ages. Results Dietary vitamin E intake, dietary and supplemental vitamin E intake, and high serum tocopherol levels were significantly associated with decreased risk of ARC, the pooled relative risk was 0·73 (95 % CI 0·58, 0·92), 0·86 (95 % CI 0·75, 0·99) and 0·77 (95 % CI 0·66, 0·91), respectively. Supplemental vitamin E intake was non-significantly associated with ARC risk (relative risk=0·92; 95 % CI 0·78, 1·07). The findings from dose–response analysis showed evidence of a non-linear association between dietary vitamin E intake and ARC. The risk of ARC decreased with dietary vitamin E intake from 7 mg/d (relative risk=0·94; 95 % CI 0·90, 0·97). Conclusions The findings of the meta-analysis indicated that dietary vitamin E intake, dietary and supplemental vitamin E intake, and high level of serum tocopherol might be significantly associated with reduced ARC risk
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| Citations per year | 0.17 |
|---|---|
| Citation span | 2020 - 2020 (1) |
| Highly cited | No |