Randomized trials assessing calcium supplementation in healthy children
Relationship between industry sponsorship and study outcomes
Bibliographic Data
| ID | 15096132 |
|---|---|
| Authors | Nancy Nkansah (California State University, Fresno, corresponding author), Thao Nguyen (0000-0003-2510-2161, California State University, Fresno), Hoda Iraninezhad (California State University, Fresno), Lisa Bero (0000-0003-1893-6651, California State University, Fresno) |
| Year | 2009 |
| Volume | 12 |
| Issue | 10 |
| Pages | 1931-1937 |
| Publication date | 2009-10-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Public Health Nutrition (JOURNAL) |
| Journal identifiers | ISSN: 1368-9800 • E-ISSN: 1475-2727 |
| Publisher | Cambridge University Press (CUP) (PUBLISHER) |
| DOI | 10.1017/s136898000900487x |
| PMID | 19254426 |
| OpenAlex | W2118410003 |
| Language | EN |
| Citations received | 2 |
| References cited | 28 |
Objective To explore the relationship between industry sponsorship of Ca supplementation studies in healthy children and study outcomes. Design An electronic search for published randomized controlled trials (RCT) was conducted. We collected data on study design features aimed at reducing bias, statistical significance of results, authors’ conclusions and financial sponsorship of study. We used Fischer’s exact test to examine associations between sponsorship and study results and conclusions. Subjects Healthy children between the ages of 9 and 18 years. Results Nineteen trials met our inclusion criteria. Seventeen out of nineteen studies reported a statistically significant improvement of supplementation on bone mineral density. Subjects in eight of the seventeen studies had a baseline daily Ca intake of 800–1300 mg. There was no significant association between study design features and the results or conclusions of the studies. Three studies received government funding, two of which (66·7 %) concluded in favour of additional supplementation. Sixteen studies were either industry-funded or had mixed industry funding, thirteen (81·3 %) of which had a conclusion supporting Ca supplementation in children. There was no significant association between study sponsorship and authors’ conclusions. Conclusions The majority of RCT assessing the effects of Ca supplementation in healthy children are industry-funded and support Ca supplementation. The clinical significance of the outcomes measured in Ca supplementation studies should be considered when examining associations between study design and results. Further non-industry funded research is needed to thoroughly assess the impact of funding on authors’ conclusions in nutrition research
Clinical trial · Environmental health · Government (linguistics · Inclusion (mineral · Physical therapy · Randomized controlled trial · Research design · Statistical significance · Health Sciences Research and Education · Medicine · Meta-analysis and systematic reviews · Pharmaceutical industry and healthcare · Psychology · Internal Medicine
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| Citations per year | 0.12 |
|---|---|
| Citation span | 2009 - 2022 (14) |
| Highly cited | No |