Aetiological factors behind adipose tissue inflammation
An unexplored research area
Bibliographic Data
| ID | 15096820 |
|---|---|
| Authors | Bernt Johan von Scholten (0000-0002-1489-0636, Copenhagen University Hospital), Erik N Andresen (Copenhagen University Hospital), Thorkild IA Sørensen (0000-0003-4821-430X, Copenhagen University Hospital), Tine Jess (0000-0002-4391-7332, Statens Serum Institut, corresponding author) |
| Year | 2013 |
| Volume | 16 |
| Issue | 1 |
| Pages | 27-35 |
| Publication date | 2013-01-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Public Health Nutrition (JOURNAL) |
| Journal identifiers | ISSN: 1368-9800 • E-ISSN: 1475-2727 |
| Publisher | Cambridge University Press (CUP) (PUBLISHER) |
| DOI | 10.1017/s1368980012000894 |
| PMID | 22464010 |
| OpenAlex | W2068706952 |
| Language | EN |
| References cited | 80 |
Objective Despite extensive research into the biological mechanisms behind obesity-related inflammation, knowledge of environmental and genetic factors triggering such mechanisms is limited. In the present narrative review we present potential determinants of adipose tissue inflammation and suggest ways ahead for future research in the field. Design We searched the literature for potential determinants of obesity with inflammation through MEDLINE by applying the MeSH headings ‘obesity’ and ‘inflammation’ in combination with specific terms for a series of environmental and genetic factors. Results Numerous articles reported on the association between environmental or genetic factors and respectively obesity and inflammation, whereas only a few studies assessed obesity and inflammation as a combined outcome. Among suggested determinants for obesity with inflammation were Adenovirus-36, the gut microbiota, trans -fatty acids, and the four genes FTO , MC4R , TNF-α and LEPR . Conclusions We present a limited number of factors potentially contributing to the development of obesity with inflammation, while concluding that overall the area is indeed sparsely investigated. We present ideas for future studies that can identify relevant aetiological factors. This identification is essential for targeted prevention of obesity with inflammation and the clinical consequences thereof
Adipose tissue · Bioinformatics · Biology · Etiology · Inflammation · Intensive care medicine · Narrative review · Obesity · Adipokines, Inflammation, and Metabolic Diseases · Adipose Tissue and Metabolism · Cardiovascular Disease and Adiposity · Medicine · Immunology · Internal Medicine
Effect of Infant Feeding on the Risk of Obesity Across the Life Course
An obesity-associated gut microbiome with increased capacity for energy harvest
Breast-feeding and childhood obesity—a systematic review
Human gut microbes associated with obesity
A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity
Fast food restaurant use among women in the Pound of Prevention study
Fast-food habits, weight gain, and insulin resistance (the Cardia study)
Epidemic obesity in the United States
| Citation velocity | historical |
|---|---|
| Highly cited | No |