Upper arm length and knee height are associated with diabetes in the middle-aged and elderly
Evidence from the China Health and Retirement Longitudinal Study
Bibliographic Data
| ID | 15096888 |
|---|---|
| Authors | Bingjie He (0000-0002-1364-7108, Peking University), Zhengyang Li (0009-0006-3976-7139, Shandong Provincial Hospital), Lu Xu (0009-0003-0179-9977, Peking University), Lili Liu (0009-0007-0747-6895, Peking University), Shengfeng Wang (0000-0001-8482-1700, Peking University, corresponding author), Siyan Zhan (0000-0001-7252-5349, Peking University, corresponding author), Yongfeng Song (0000-0001-8934-3154, Shandong Provincial Hospital, corresponding author) |
| Year | 2023 |
| Volume | 26 |
| Issue | 1 |
| Pages | 190-198 |
| Publication date | 2023-01-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Public Health Nutrition (JOURNAL) |
| Journal identifiers | ISSN: 1368-9800 • E-ISSN: 1475-2727 |
| Publisher | Cambridge University Press (CUP) (PUBLISHER) |
| DOI | 10.1017/s1368980022001215 |
| PMID | 35581171 |
| OpenAlex | W4280545923 |
| Language | EN |
| Citations received | 2 |
| References cited | 47 |
Objective: To determine if limb lengths, as markers of early life environment, are associated with the risk of diabetes in China. Design: We performed a cohort analysis using data from the China Health and Retirement Longitudinal Study (CHARLS), and multivariable-adjusted Cox proportional hazard regression models were used to examine the associations between baseline limb lengths and subsequent risk of diabetes. Setting: The CHARLS, 2011–2018. Participants: The study confined the eligible subject to 10 711 adults aged over 45 years from the CHARLS. Results: During a mean follow-up period of 6·13 years, 1358 cases of incident diabetes were detected. When controlling for potential covariates, upper arm length was inversely related to diabetes (hazard ratio (HR) 0·95, 95 % CI (0·91, 0·99), P = 0·028), and for every 1-cm difference in knee height, the risk of diabetes decreased by about 4 % (HR 0·96, 95 % CI (0·93, 0·99), P = 0·023). The association between upper arm length and diabetes was only significant among females while the association between knee height and diabetes was only significant among males. In analyses stratified by BMI, significant associations between upper arm length/knee height and diabetes only existed among those who were underweight (HR 0·91, 95 % CI (0·83, 1·00), P = 0·049, HR 0·92, 95 % CI (0·86, 0·99), P = 0·031). Conclusions: Inverse associations were observed between upper arm length, knee height and the risk for diabetes development in a large Asian population, suggesting early life environment, especially infant nutritional status, may play an important role in the determination of future diabetes risk
Cohort · Cohort study · Confidence interval · Diabetes mellitus · Environmental health · Hazard ratio · Longitudinal study · Population · Proportional hazards model · Prospective cohort study · Birth, Development, and Health · Demography · Gestational Diabetes Research and Management · Medicine · Obesity, Physical Activity, Diet · Endocrinology · Internal Medicine
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| Citations per year | 0.5 |
|---|---|
| Citation span | 2022 - 2025 (4) |
| Highly cited | No |