A dose–response meta-analysis reveals an association between vitamin B 12 and colorectal cancer risk

Bibliographic Data

ID15096965
AuthorsNai-Hui Sun, Naihui Sun (0000-0002-4423-1420, First Hospital of China Medical University), Xuan-Zhang Huang, Xuanzhang Huang (0000-0001-9886-7152, First Hospital of China Medical University), Shuai-Bo Wang (People's Government of Shaanxi Province), Yuan Li (0000-0001-7139-4391, First Hospital of China Medical University), Long-Yi Wang (First Hospital of China Medical University), Hong-Chi Wang (First Hospital of China Medical University), Chang-Wang Zhang (First Hospital of China Medical University), Cong Zhang (0000-0002-2561-2113, First Hospital of China Medical University), Hongpeng Liu (0000-0002-7494-9097, First Hospital of China Medical University), Hong-Peng Liu, Zhen-Ning Wang (First Hospital of China Medical University, corresponding author)
Year2016
Volume19
Issue8
Pages1446-1456
Publication date2016-06-01
Open AccessYes
TypeARTICLE
VenuePublic Health Nutrition (JOURNAL)
Journal identifiersISSN: 1368-9800 • E-ISSN: 1475-2727
PublisherCambridge University Press (CUP) (PUBLISHER)
DOI10.1017/s136898001500261x
PMID26373257
OpenAlexW1913505840
LanguageEN
References cited47

Objective The current meta-analysis evaluated the association between vitamin B 12 intake and blood vitamin B 12 level and colorectal cancer (CRC) risk. Design The PubMed and EMBASE databases were searched. A dose–response analysis was performed with generalized least squares regression, with the relative risk (RR) and 95 % CI as effect values. Setting The meta-analysis included seventeen studies. Subjects A total of 10 601 patients. Results The non-linear dose–response relationship between total vitamin B 12 intake and CRC risk was insignificant ( P =0·690), but the relationship between dietary vitamin B 12 intake and CRC risk was significant ( P 12 intake was inversely associated with CRC risk (total intake: RR=0·963; 95 % CI 0·928, 0·999; dietary intake: RR=0·914; 95 % CI 0·856, 0·977). The inverse association between vitamin B 12 intake and CRC risk was also significant when vitamin B 12 intake was over a dosage threshold, enhancing the non-linear relationship. The non-linear dose–response relationship between blood vitamin B 12 level and CRC risk was insignificant ( P =0·219). There was an insignificant association between every 150 pmol/l increment in blood vitamin B 12 level and CRC risk (RR=1·023; 95 % CI 0·881, 1·187). Conclusions Our meta-analysis indicates that evidence supports the use of vitamin B 12 for cancer prevention, especially among populations with high-dose vitamin B 12 intake, and that the association between CRC risk and total vitamin B 12 intake is stronger than between CRC risk and dietary vitamin B 12 intake only

Cancer · Colorectal cancer · Confidence interval · Meta-analysis · Relative risk · Vitamin · Vitamin B12 · Antioxidant Activity and Oxidative Stress · Folate and B Vitamins Research · Medicine · Retinoids in leukemia and cellular processes · Gastroenterology · Internal Medicine

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