Association between vitamin B 12 -containing supplement consumption and prevalence of biochemically defined B 12 deficiency in adults in NHANES III (Third National Health and Nutrition Examination Survey)
Bibliographic Data
| ID | 15097149 |
|---|---|
| Authors | Marian L Evatt (Emory University), Paul Terry (0000-0002-0353-9197, Emory University, corresponding author), Paul D Terry, Thomas R Ziegler (0000-0001-9329-1481, Emory University), Godfrey P Oakley (0000-0003-2185-3929, Emory University) |
| Year | 2010 |
| Volume | 13 |
| Issue | 1 |
| Pages | 25-31 |
| Publication date | 2010-01-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Public Health Nutrition (JOURNAL) |
| Journal identifiers | ISSN: 1368-9800 • E-ISSN: 1475-2727 |
| Publisher | Cambridge University Press (CUP) (PUBLISHER) |
| DOI | 10.1017/s1368980009990279 |
| PMID | 19519972 |
| PMCID | PMC3066843 |
| OpenAlex | W2106379001 |
| Language | EN |
| References cited | 29 |
Objective To explore the association between vitamin B 12 (B 12 )-containing supplement use, low B 12 concentrations and biochemically defined B 12 deficiency in US adults. Design A cross-sectional study with adjustment for survey design. Prevalence ratios for two age groups (18–50 and >50 years) were estimated using unconditional logistic models. Outcome measures included prevalence of low serum B 12 concentration ( 12 deficiency (serum B 12 10 μmol/l). Setting A population survey of health and nutritional measures. Subjects Subjects were non-institutionalized adults, aged 18 years and older, who participated in Phase 2 of NHANES III (Third National Health and Nutrition Examination Survey). Results Low B 12 concentrations were less prevalent among persons consuming B 12 -containing supplements ( P = 0·001) with an adjusted prevalence ratio of 0·6 (95 % CI 0·3, 1·0). Biochemical B 12 deficiency showed a similar trend ( P = 0·0002), with an adjusted prevalence ratio of 0·3 (95 % CI 0·1, 0·8). Prevalence ratios were similar in adults >50 years of age, although the prevalence of low B 12 and biochemical deficiency was proportionally higher. Conclusions Consumption of B 12 -containing supplements was associated with at least 50 % lower prevalence of both low serum B 12 and biochemical B 12 deficiency in a nationally representative sample of US adults, suggesting increased consumption of B 12 from supplements or from fortified foods may reduce the prevalence of B 12 deficiency. Additionally, the current Recommended Daily Allowance for B 12 of 2·4 μg may be insufficient for those aged >50 years
Biology · Cross-sectional study · Dietary Reference Intake · Environmental health · Logistic regression · National Health and Nutrition Examination Survey · Nutrient · Odds ratio · Population · Demography · Esophageal and GI Pathology · Fluoride Effects and Removal · Folate and B Vitamins Research · Medicine · Internal Medicine
| Citation velocity | historical |
|---|---|
| Highly cited | No |