Association between 24-h urinary sodium to potassium ratio and mild cognitive impairment in community-based general population

Objective: To explore the relationship between parameters of Na and K excretion using 24-h urine sample and mild cognitive impairment (MCI) in general population. Design: This is a cross-sectional study. Setting: Community-based general population in Emin China. Participants: Totally, 1147 subjects aged ≥18 years were selected to complete the study, with a multistage proportional random sampling method. Cognitive status was assessed with Mini Mental State Examination (MMSE) questionnaire and timed 24-h urine specimens were collected. Finally, 561 participants aged ≥35 years with complete urine sample and MMSE data were included for the current analysis and divided into groups by tertiles of 24-h urinary sodium to potassium ratio (24-h UNa/K) as lowest (T1), middle (T2) and highest (T3) groups. Results: The MMSE score was significantly lower in T3, compared with the T1 group (26·0 v . 25·0, P = 0·002), and the prevalent MCI was significantly higher in T3 than in T1 group (11·7 % v . 25·8 %, P β : −0·184, 95 % CI −0·319, −0·050, P = 0·007) was negatively associated with MMSE score. In multivariable logistic regression, compared with T1 group, 24-h UNa/K in the T2 and T3 groups showed 2·01 (95 % CI 1·03, 3·93, P = 0·041) and 3·38 (95 % CI 1·77, 6·44, P Conclusions: Higher 24-h UNa/K is in an independent association with prevalent MCI

Association (psychology · Cognitive impairment · Population · Potassium · Sodium · Urinary system · Electrolyte and hormonal disorders · Ion Transport and Channel Regulation · Sodium Intake and Health

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