Iron intake with the risk of breast cancer among Chinese women
A case–control study
Bibliographic Data
| ID | 15097612 |
|---|---|
| Authors | Kai-Yan Liu, Kai‐Yan Liu (0000-0002-6751-7827, Sun Yat-sen University), Xiaoli Feng (0000-0002-5336-521X, Sun Yat-sen University), Xiao-Li Feng, Xiong-Fei Mo, Xiong‐Fei Mo (The First Affiliated Hospital, Sun Yat-sen University), Fang-Yu Lin, Fang‐Yu Lin (Sun Yat-sen University), Xin Zhang (0000-0003-0184-5868, Sun Yat-sen University), Chu-Yi Huang, Chuyi Huang (0000-0002-0326-8470, Sun Yat-sen University), Alinuer Abulimiti (Sun Yat-sen University), Lei Li (0000-0002-0388-7933, Sun Yat-sen University), Cai‐Xia Zhang (0000-0001-9671-9412, Sun Yat-sen University, corresponding author), Cai-Xia Zhang |
| Year | 2021 |
| Volume | 24 |
| Issue | 17 |
| Pages | 5743-5755 |
| Publication date | 2021-12-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Public Health Nutrition (JOURNAL) |
| Journal identifiers | ISSN: 1368-9800 • E-ISSN: 1475-2727 |
| Publisher | Cambridge University Press (CUP) (PUBLISHER) |
| DOI | 10.1017/s1368980021000471 |
| PMID | 33618790 |
| OpenAlex | W3133114133 |
| Language | EN |
| References cited | 52 |
Objective: The current study evaluated the associations between different forms and sources of Fe and breast cancer risk in Southern Chinese women. Design: Case–control study. We collected data on the consumption of Fe from different forms and food sources by using a validated FFQ. Multivariable logistic regression and restricted cubic spline (RCS) analysis was used to reveal potential associations between Fe intake and breast cancer risk. Setting: A case-control study of women at three major hospitals in Guangzhou, China. Participants: From June 2007 to March 2019, 1591 breast cancer cases and 1622 age-matched controls were recruited. Results: In quartile analyses, Fe from plants and Fe from white meat intake were inversely associated with breast cancer risk, with OR of 0·65 (95 % CI 0·47, 0·89, P trend = 0·006) and 0·76 (95 % CI 0·61, 0·96, P trend = 0·014), respectively, comparing the highest with the lowest quartile. No associations were observed between total dietary Fe, heme or non-heme Fe, Fe from meat or red meat and breast cancer risk. RCS analysis demonstrated J-shaped associations between total dietary Fe, non-heme Fe and breast cancer, and reverse L-shaped associations between heme Fe, Fe from meat and Fe from red meat and breast cancer. Conclusion: Fe from plants and white meat were inversely associated with breast cancer risk. Significant non-linear J-shaped associations were found between total dietary Fe, non-heme Fe and breast cancer risk, and reverse L-shaped associations were found between heme Fe, Fe from meat or red meat and breast cancer risk
Breast cancer · Cancer · Case-control study · Confidence interval · Logistic regression · Pathology · Quartile · Red meat · White meat · Chemistry · Iron Metabolism and Disorders · Medicine · Nutritional Studies and Diet · Trace Elements in Health · Food Science · Internal Medicine
| Citation velocity | historical |
|---|---|
| Highly cited | No |