High societal costs and reduced health-related quality of life in inflammatory and systemic immune disease-associated dilated cardiomyopathies
Bibliographic Data
Dilated cardiomyopathy (DCM) comes with an estimated societal cost of above €10,000 per patient per year and a lower quality of life (QoL). However, DCM represents a heterogeneous disease with different aetiologies that can be combined in subgroups. Insight in QoL and societal costs per DCM subgroup may guide resource allocation, research focus areas, and tailored patient management. We investigated subgroup-specific costs and QoL in patients with DCM. Patients with DCM (n = 550) were included, all phenotyped by endomyocardial biopsy and genetic testing besides routine cardiac evaluation. Patients were classified as chemotherapy-induced DCM (n = 27), genetic DCM (n = 91), inflammatory DCM (n = 53), systemic immune-mediated disease (SID)-associated DCM (n = 83), alcohol-induced DCM (n = 40), and idiopathic DCM (n = 280). QoL and societal costs were cross-sectionally evaluated using the EQ-5D-5 L and the iMTA medical and productivity cost questionnaires, sent at 8 [IQR 5; 12] years after cardiomyopathy diagnosis. Compared to other subgroups, QoL was lower for inflammatory DCM (-0.053 [-0.106; -0.003], p = 0.04), SID-associated DCM (-0.078 [-0.126; -0.031], p 10.000€ per patient per year while impacting quality of life. Dilated cardiomyopathy is a heterogeneous disease with diverse aetiologies. Understanding underlying the impact of each aetiology on costs and quality of life may further guide resource allocation and patient management. Aetologies of dilated cardiomyopathy come with their own societal cost characteristics and quality of life impact. Inflammatory, systemic immune disease-associated, and alcohol-induced dilated cardiomyopathy have a worse quality of life, while the former two come with higher societal costs. These findings help us in tailoring patient management such as in patient education, financial counseling, and psychological support
Cardiology · Cardiomyopathy · Dilated cardiomyopathy · Disease · Health related quality of life · Heart failure · Immune system · Intensive care medicine · Pathology · Public health · Quality of life (healthcare · Quality of Life Research · Cardiac pacing and defibrillation studies · Cardiomyopathy and Myosin Studies · Medicine · Nursing · Viral Infections and Immunology Research · Immunology · Internal Medicine
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