Tobacco growing in Uganda
The environment and women pay the price
Bibliographic Data
| ID | 15305232 |
|---|---|
| Authors | H Muwanga-Bayego (corresponding author) |
| Year | 1994 |
| Volume | 3 |
| Issue | 3 |
| Pages | 255-256 |
| Publication date | 1994-09-01 |
| Open Access | No |
| Type | ARTICLE |
| Venue | Tobacco Control (JOURNAL) |
| Journal identifiers | ISSN: 0964-4563 • E-ISSN: 1468-3318 |
| Publisher | BMJ (PUBLISHER • GB) |
| DOI | 10.1136/tc.3.3.255 |
| OpenAlex | W2025565230 |
| Language | EN |
| Citations received | 3 |
Once folded, natural protein molecules have few energetic conflicts within their polypeptide chains. Many protein structures do however contain regions where energetic conflicts remain after folding, i. e. they have highly frustrated regions. These regions, kept in place over evolutionary and physiological timescales, are related to several functional aspects of natural proteins such as protein-protein interactions, small ligand recognition, catalytic sites and allostery. Here we present FrustratometeR, an R package that easily computes local energetic frustration on a personal computer or a cluster. This package facilitates large scale analysis of local frustration, point mutants and molecular dynamics (MD) trajectories, allowing straightforward integration of local frustration analysis into pipelines for protein structural analysis. Contact [email protected] Availability and implementation https://github.com/proteinphysiologylab/frustratometeR
Allosteric regulation · Biology · Cluster (spacecraft · Computational biology · Folding (DSP implementation · Frustration · Protein folding · Receptor · Computer Science · Engineering · Genetics, Bioinformatics, and Biomedical Research · Machine Learning in Bioinformatics · Neuroscience · Protein Structure and Dynamics · Biochemistry · Genetics
| Citations per year | 0.12 |
|---|---|
| Citation span | 2000 - 2016 (17) |
| Highly cited | No |