Relationship between Heart Rate Variability and Postoperative Cognitive Dysfunction in Elderly Patients

Bibliographic Data

ID15329211
AuthorsXuelian Li (0000-0002-5022-7209, Associate Professor, Department of Anesthesiology, The Affiliated Hospital of Southwest Medical University, Anesthesiology and Critical Care Medicine Key Laboratory of Luzhou, Southwest Medical University, Department of Anesthesiology, Southwest Medical University, Luzhou, China, corresponding author), Xiren Deng (Associate Professor, Department of Anesthesiology, The Affiliated Hospital of Southwest Medical University, Anesthesiology and Critical Care Medicine Key Laboratory of Luzhou, Southwest Medical University, Department of Anesthesiology, Southwest Medical University, Luzhou, China), Zhiwei Huang (0000-0002-6312-7434, Southwest Medical University), Ana Kowark (0000-0002-7433-8675, University Hospital Bonn), Mark Coburn (0000-0002-7930-0270, University Hospital Bonn), Guanpeng Zhang (Department of Electrocardiogram, The Affiliated Hospital of Southwest Medical University, Luzhou, China;, Email: [email protected]), Xiaoxia Duan (0000-0002-0178-9950, Affiliated Hospital of Southwest Medical University)
Year2023
Volume47
Issue1
Pages65-74
Publication date2023-02-28
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueAmerican Journal of Health Behavior (JOURNAL)
Journal identifiersISSN: 1087-3244 • E-ISSN: 1945-7359
PublisherPNG Publications (PUBLISHER • US)
DOI10.5993/ajhb.47.1.8
PMID36945090
OpenAlexW4353014867
LanguageEN
References cited37

Objectives: Postoperative cognitive dysfunction (POCD) is objectively measurable after anesthesia and surgery. Lower heart rate variability (HRV) is associated with poorer cognitive performance, but the relationship between HRV and POCD remains unclear. Methods: Elderly patients who underwent total hip replacement under general anesthesia from the Department of Bone and Joint Surgery, Affiliated Hospital of Southwest Medical University were enrolled. Neuropsychological tests, standard deviation of the interbeat interval (SDNN, a parameter of HRV), and plasma concentrations of glial cell line-derived neurotrophic factors (GDNF) were performed one day before (T -1 ) and 7 days after (T 7 ) surgery. Results: POCD occurred in 35% of patients on 7 days after surgery. Lower SDNN(T 7 ) (OR=.91) and longer surgery time (OR=1.33) were associated with POCD. Compared with patients without POCD, there was higher variation SDNN (Δ SDNN) and plasma GDNF (ΔGDNF) in those with POCD from T -1 to T 7 period. ΔGDNF is positively correlated with ΔSDNN (r = .61, p Conclusions: Lower SDNN (T 7 ) was associated with POCD and might be used as a warning indicator for the risk of POCD

Anesthesia · Blood pressure · Cognition · Glial cell line-derived neurotrophic factor · Heart rate · Heart rate variability · Neurotrophic factors · Postoperative cognitive dysfunction · Psychiatry · Cardiac, Anesthesia and Surgical Outcomes · Heart Rate Variability and Autonomic Control · Intensive Care Unit Cognitive Disorders · Medicine · Internal Medicine

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