Exploring the Use of Oral Pre-exposure Prophylaxis (PrEP) Among Women from Durban, South Africa as Part of the HIV Prevention Package in a Clinical Trial
Bibliographic Data
| ID | 15335484 |
|---|---|
| Authors | Ivana Beesham (0000-0003-4889-8123, University of the Witwatersrand, corresponding author), Renee Heffron (0000-0001-6039-0352, University of Washington), Shannon Evans (University of the Witwatersrand), Jared M Baeten (0000-0001-8242-8438, University of Washington), Jenni Smit (University of the Witwatersrand), Mags Beksinska (0000-0002-4169-4112, University of the Witwatersrand), Leila E Mansoor (0000-0002-7607-348X, University of KwaZulu-Natal) |
| Year | 2020 |
| Volume | 25 |
| Issue | 4 |
| Pages | 1112-1119 |
| Publication date | 2020-10-26 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | AIDS and Behavior (JOURNAL) |
| Journal identifiers | ISSN: 1090-7165 • E-ISSN: 1573-3254 |
| Publisher | Springer Science+Business Media (PUBLISHER • DE) |
| DOI | 10.1007/s10461-020-03072-0 |
| PMID | 33106996 |
| OpenAlex | W3093951474 |
| Language | EN |
| Citations received | 15 |
| References cited | 9 |
HIV endpoint-driven clinical trials in Africa enroll women who are at heightened risk of acquiring HIV. In 2017, the South African Medical Research Council recommended the provision of oral pre-exposure prophylaxis (PrEP) in HIV prevention trials, at which time the Evidence for Contraceptive Options and HIV Outcomes trial was ongoing and began to provide PrEP on-site at some trial sites. We interviewed 132 women who initiated PrEP on-site at the Durban, South Africa trial site to explore PrEP use, and conducted phone-based interviews 4-6 months post-trial exit to explore post-trial PrEP access. PrEP uptake was high (42.6%). Among women initiating PrEP on-site, 87.9% felt at risk of acquiring HIV. Most women (> 90%) heard of PrEP for the first time from study staff and three-quarters who initiated PrEP on-site continued at trial-exit. PrEP use declined post-trial exit with more than 50% of women discontinuing PrEP, and barriers relating to access emerged
Alternative medicine · Clinical trial · Family medicine · Health psychology · Human immunodeficiency virus (HIV · Men who have sex with men · Pre-exposure prophylaxis · Public health · HIV, Drug Use, Sexual Risk · HIV/AIDS Research and Interventions · Medicine · Nursing · Sex work and related issues · Internal Medicine
A Systematic Review of Barriers and Facilitators to the Uptake and Adherence of Injectable PrEP Among Adolescent Girls and Young Women in Sub-Saharan Africa
Pre-exposure prophylaxis persistence at two sites in an integrated primary health care programme in South Africa
Motivators for oral PrEP uptake and adherence in the eThekwini municipality, KwaZulu-Natal
Daily Oral Pre-exposure Prophylaxis (PrEP) Continuation Among Women from Durban, South Africa, Who Initiated PrEP as Standard of Care for HIV Prevention in a Clinical Trial
PrEP Awareness and Coverage
Study-to-Clinic Transition and Daily Oral PrEP Access Experiences Among Agyw in Eastern Cape, South Africa
Prevention-of-mother-to-child-transmission (PMTCT) program outcomes in South Africa in the pre-Covid and Covid eras
Post-trial access to and use of pre-exposure prophylaxis in Durban, South Africa
Women’s Perceptions of HIV- and Sexuality-Related Stigma in Relation to PrEP
Preferences for Delivery of HIV Prevention Services Among Healthcare Users in South Africa
Trajectories of Oral PrEP Adherence Among Young Kenyan Women
Integrating PrEP and Sexual Reproductive Health Services for Adolescent Girls and Young Women in South Africa
Yes, I’m reminded, but it doesn’t mean I’m taking them”
Strategies to Close the PrEP Uptake Gap Among Transgender People and Men Who Have Sex with Men in Tshwane, South Africa
Barriers to Oral HIV Pre-exposure Prophylaxis (PrEP) Adherence Among Pregnant and Post-partum Women from Cape Town, South Africa
HIV pre‐exposure prophylaxis for adolescent girls and young women in Africa
Preexposure Prophylaxis for HIV Infection among African Women
Women’s Experiences with Oral and Vaginal Pre-Exposure Prophylaxis
Tenofovir-Based Preexposure Prophylaxis for HIV Infection among African Women
The influence of HIV‐related stigma on PrEP disclosure and adherence among adolescent girls and young women in HPTN 082
| Citations per year | 3.75 |
|---|---|
| Citation span | 2022 - 2026 (5) |
| Highly cited | No |