Real-Time Adherence Monitoring for HIV Antiretroviral Therapy
Bibliographic Data
| ID | 15338342 |
|---|---|
| Authors | Jessica E Haberer (0000-0001-5845-3190, Center for Global Health, corresponding author), Josh Kahane (Harvard Global Health Institute), Isaac Kigozi (Mbarara University of Science and Technology), Nneka Emenyonu (0000-0003-4376-7810, Mbarara University of Science and Technology), Peter W Hunt (0000-0002-4571-4870, University of California, San Francisco), Peter Hunt (0000-0002-7227-5623), Judith N Martins (0000-0002-9773-3256, University of California, San Francisco), Jeffrey Martin (0000-0001-5070-7432), David R Bangsberg (0000-0002-6352-8908, Center for Global Health) |
| Year | 2010 |
| Volume | 14 |
| Issue | 6 |
| Pages | 1340-1346 |
| Publication date | 2010-08-30 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | AIDS and Behavior (JOURNAL) |
| Journal identifiers | ISSN: 1090-7165 • E-ISSN: 1573-3254 |
| Publisher | Springer Science+Business Media (PUBLISHER • DE) |
| DOI | 10.1007/s10461-010-9799-4 |
| PMID | 20809380 |
| PMCID | PMC2974938 |
| OpenAlex | W2109168061 |
| Language | EN |
| Citations received | 54 |
| References cited | 23 |
Current adherence assessments typically detect missed doses long after they occur. Real-time, wireless monitoring strategies for antiretroviral therapy may provide novel opportunities to proactively prevent virologic rebound and treatment failure. Wisepill, a wireless pill container that transmits a cellular signal when opened, was pilot tested in ten Ugandan individuals for 6 months. Adherence levels measured by Wisepill, unannounced pill counts, and self-report were compared with each other, prior standard electronic monitoring, and HIV RNA. Wisepill data was initially limited by battery life and signal transmission interruptions. Following device improvements, continuous data was achieved with median (interquartile range) adherence levels of 93% (87-97%) by Wisepill, 100% (99-100%) by unannounced pill count, 100% (100-100%) by self-report, and 92% (79-98%) by prior standard electronic monitoring. Four individuals developed transient, low-level viremia. After overcoming technical challenges, real-time adherence monitoring is feasible for resource-limited settings and may detect suboptimal adherence prior to viral rebound
Antiretroviral therapy · Human immunodeficiency virus (HIV · Intensive care medicine · Interquartile range · Pill · Viral load · Viremia · HIV Research and Treatment · HIV/AIDS drug development and treatment · HIV/AIDS Research and Interventions · Medicine · Emergency Medicine · Immunology · Internal Medicine · Pharmacology
Impact of Geographic and Transportation-Related Barriers on HIV Outcomes in Sub-Saharan Africa
Defining success with HIV pre-exposure prophylaxis
Applying convergent parallel mixed methods design to investigate medication adherence among people living with HIV in resource-limited settings
Qualitative Identification of Intervention Preferences to Support Men’s Engagement and Retention in TB Care in South Africa
The Vuka family program
Experience with antiretroviral electronic adherence monitoring among young African American men who have sex with men living with HIV
Lessons learned from a mobile technology-based intervention informed by behavioral economics to improve ART adherence among youth in Uganda
Alcohol-antiretroviral therapy interactive toxicity beliefs and daily medication adherence and alcohol use among people living with HIV
Moderating effects of social support on the relationship between substance use disorders and HIV viral load and medication adherence among Black women living with HIV in the United States
Resilience after withdrawing a technology-based medication adherence support intervention from people living with HIV in rural Uganda
Interventions to enhance HIV medication adherence among individuals using substances
The Relationship Between Harmful Alcohol Use and Antiretroviral Non-adherence in People Accessing HIV Treatment in Cape Town, South Africa
Addressing Syndemics and Self-care in Individuals with Uncontrolled HIV
Retention in HIV Care Among HIV-Seropositive Pregnant and Postpartum Women in Uganda
A Novel Breath Test to Directly Measure Use of Vaginal Gel and Condoms
True Durability
Monitoring Microbicide Gel Use with Real-Time Notification of the Container’s Opening Events
Acceptability and Feasibility of Providing Adherence Feedback Based on Tenofovir Diphosphate in Dried Blood Spots
Novel Approaches for Visualizing and Analyzing Dose-Timing Data from Electronic Drug Monitors, or “How the ‘Broken Window’ Theory Pertains to ART Adherence”
Feasibility of Real Time Medication Monitoring Among HIV Infected and TB Patients in a Resource-Limited Setting
Use of a Novel Technology to Track Adherence to Product Use in a Microbicide Trial of Short Duration (MTN-007)
Electronic Adherence Monitoring May Facilitate Intentional HIV Status Disclosure Among People Living with HIV in Rural Southwestern Uganda
Gendered Racial Microaggressions, Self-silencing, Substance Use, and HIV Outcomes Among Black Women Living with HIV
Picture Pill Count
Multiple Dimensions of Stigma and Health Related Factors Among Young Black Men Who Have Sex with Men
Explaining Antiretroviral Therapy Adherence Success Among HIV-Infected Children in Rural Uganda
A Randomized Controlled Trial Examining the Efficacy of Motivational Counseling with Observed Therapy for Antiretroviral Therapy Adherence
Mechanism of Change in Cognitive Behavioral Therapy for Body Image and Self-Care on ART Adherence Among Sexual Minority Men Living with HIV
Can Short-Term Use of Electronic Patient Adherence Monitoring Devices Improve Adherence in Patients Failing Second-Line Antiretroviral Therapy? Evidence from a Pilot Study in Johannesburg, South Africa
Randomized Controlled Trial of Automated Directly Observed Therapy for Measurement and Support of PrEP Adherence Among Young Men Who have Sex with Men
Gender Moderates Results of a Randomized Clinical Trial for the Khanya Intervention for Substance Use and ART Adherence in HIV Care in South Africa
Barriers to Medication Adherence in Behaviorally and Perinatally Infected Youth Living with HIV
Cognitive Performance, as well as Depression, Alcohol Use, and Gender, predict Anti-Retroviral Therapy Adherence in a South African Cohort of People with HIV and Comorbid Major Depressive Disorder
If You Build It, Will They Use It? Preferences for Antiretroviral Therapy (ART) Adherence Monitoring Among People Who Inject Drugs (PWID) in Kazakhstan
Mental Health, Self-Care, and Engagement in Care among Black Women Living with HIV
Pesky metrics
Syndemic indicators predict poor medication adherence and increased healthcare utilization for urban HIV-positive men who have sex with men
Suubi+Adherence-Round 2
A community health worker and mobile health app intervention to improve adherence to HIV medication among persons with HIV
Protocol of the randomized control trial
Study protocol to evaluate an integrated intervention using a pill ingestible sensor system to trigger actions on multifaceted social and behavioral determinants of health among PLWH
Real-time monitoring and just-in-time intervention for adherence to pre-exposure prophylaxis among men who have sex with men in China
Factors associated with HIV positive sero-status among exposed infants attending care at health facilities
Feasibility and Acceptability of Real-Time Antiretroviral Adherence Monitoring among Depressed Women Living with HIV in the Deep South of the US
A Pilot Randomized Control Trial of the Striving Towards EmPowerment and Medication Adherence (STEP-AD) Intervention for Black Women Living with HIV
Correlation of Adherence by Pill Count, Self-report, Mems and Plasma Drug Levels to Treatment Response Among Women Receiving ARV Therapy for PMTCT in Kenya
Ugandan Study Participants Experience Electronic Monitoring of Antiretroviral Therapy Adherence as Welcomed Pressure to Adhere
Feasibility and Acceptability of a Task-Shifted Intervention to Enhance Adherence to HIV Medication and Improve Depression in People Living with HIV in Zimbabwe, a Low Income Country in Sub-Saharan Africa
Feasibility, Performance, and Acceptability of the WisebagTM for Potential Monitoring of Daily Gel Applicator Use in Durban, South Africa
Short Message Service (SMS) Surveys Assessing Pre-exposure Prophylaxis (PrEP) Adherence and Sexual Behavior are Highly Acceptable Among HIV-Uninfected Members of Serodiscordant Couples in East Africa
Adherence to Oral HIV Pre-exposure Prophylaxis During Pregnancy and the Post-partum Period
Duration of Viral Suppression and Risk of Rebound Viremia with First-Line Antiretroviral Therapy in Rural Uganda
Supporting Adolescents to Adhere (Sata)
A pilot study of a nurse-delivered cognitive behavioral therapy intervention (Ziphamandla) for adherence and depression in HIV in South Africa
The Technology Acceptance Model
Efficacy of Antiretroviral Therapy Adherence Interventions
Multiple Validated Measures of Adherence Indicate High Levels of Adherence to Generic HIV Antiretroviral Therapy in a Resource-Limited Setting
Self-Report Measures of Antiretroviral Therapy Adherence
Non-adherence to highly active antiretroviral therapy predicts progression to Aids
Adherence to protease inhibitors, HIV-1 viral load, and development of drug resistance in an indigent population
Intermittent use of triple-combination therapy is predictive of mortality at baseline and after 1 year of follow-up
User Acceptance of Information Technology
Perceived Usefulness, Perceived Ease of Use, and User Acceptance of Information Technology
Longitudinal Antiretroviral Adherence in HIV+ Ugandan Parents and Their Children Initiating Haart in the MTCT-Plus Family Treatment Model
| Unique citing works | 54 |
|---|---|
| Citations per year | 3,86 |
| Citation span | 2012 - 2026 (15) |
| Citation velocity | current |
| Highly cited | No |
| Citation types | Neutral: 54 |