Quantifying the interaction between adiposity and hyperglycemia on incident asthma among youth
Bibliographic Data
| ID | 15364787 |
|---|---|
| Authors | Guobo Li (0000-0003-4909-4178, Fujian Medical University), Yingying Lin (0000-0002-8631-5833, Fujian Medical University), Zhiwei Wu (0000-0002-0672-948X, Fujian Medical University), Jingmin Guo (Fujian Medical University, corresponding author) |
| Year | 2026 |
| Volume | 26 |
| Issue | 1 |
| Publication date | 2026-03-24 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | BMC Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1471-2458 • E-ISSN: 1471-2458 |
| Publisher | BioMed Central (PUBLISHER • GB) |
| DOI | 10.1186/s12889-026-26967-4 |
| PMID | 41877051 |
| OpenAlex | W7140171954 |
| Language | EN |
| References cited | 56 |
This study aimed to investigate the association between overweight and diabetes with childhood asthma and to assess potential synergistic effects among these conditions. This cross - sectional study analyzed 14,281 US children aged 2–17 years (NHANES 1999–2023). Active asthma was defined as the outcome. Overweight and diabetes were the exposure variables. Multivariable logistic regression models were used to assess the association between overweight, diabetes, and asthma risk. The models were adjusted for demographics, HDL, hypertension, poverty - income ratio, and physical activity. Both overweight and diabetes were associated with increased asthma risk in children, with an interaction effect between the two conditions. After adjusting for confounders, children with both overweight and diabetes had a significantly increased asthma risk (OR 3.861, 95% CI 1.02–14.63). Subgroup analysis demonstrated that the positive association between overweight/diabetes and asthma risk remained consistent across most demographic and clinical strata, with no significant interactions observed, confirming the robustness of the findings across diverse populations. Adiposity and hyperglycaemia synergistically amplify childhood asthma risk, especially in adolescents and inactive youth, underscoring integrated metabolic–respiratory prevention strategies
Asthma · Biostatistics · Diabetes mellitus · Logistic regression · Obesity · Overweight · Public health · Asthma and respiratory diseases · Chronic Obstructive Pulmonary Disease (COPD) Research · Delphi Technique in Research
Clinical Practice Guideline for Screening and Management of High Blood Pressure in Children and Adolescents
Predicting adult obesity from childhood obesity
Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013
Interaction between obesity and asthma in children and adolescents with hypertension based on NHANES 2007–2020
| Citation velocity | historical |
|---|---|
| Highly cited | No |