Hormones, oxidized proteins, and lipids in alcoholism. Duration of remission
Bibliographic Data
| ID | 15415198 |
|---|---|
| Authors | Т П Ветлугина (0000-0003-2068-0931, Russian Academy of Sciences, corresponding author), V D Prokopieva (0000-0002-4811-984X, Russian Academy of Sciences), Н А Бохан (0000-0002-1052-855X, Russian Academy of Sciences), В Б Никитина (0000-0002-1644-770X, Russian Academy of Sciences), О А Лобачева (0000-0002-7477-6296, Russian Academy of Sciences), А И Мандель (0000-0002-6020-6604, Russian Academy of Sciences) |
| Year | 2023 |
| Volume | 23 |
| Issue | 3 |
| Pages | 569-585 |
| Publication date | 2023-11-20 |
| Open Access | No |
| Type | ARTICLE |
| Venue | Journal of Ethnicity in Substance Abuse (JOURNAL) |
| Journal identifiers | ISSN: 1533-2640 • E-ISSN: 1533-2659 |
| Publisher | Taylor & Francis (PUBLISHER • GB) |
| DOI | 10.1080/15332640.2023.2280089 |
| PMID | 37982405 |
| OpenAlex | W4388827921 |
| Language | EN |
| References cited | 43 |
The instability of remission in alcohol dependence (AD) creates a need to search for criteria for predicting its duration. The aim of study was to determine the hormones, oxidized proteins, and lipids in patients with AD, and the possible relations between these parameters and the duration of remission. Blood samples were obtained from 49 male patients with AD after alcohol detoxification (Total group). Two groups of patients were formed: with unstable therapeutic remission up to 6 months (UTR-group); with stable therapeutic remission which lasted 12 months or longer (STR-group). The control group comprised men without AD. The levels of carbonylated proteins (CP), lipid peroxidation (TBA-RS) were determined in the blood plasma. The levels of cortisol, testosterone total, thyroid-stimulating hormone (TSH), triiodothyronine free (fT3), and thyroxine free (fT4) in the blood serum were measured. The Total group of patients showed an increase in CP, TBA-RS, Cortisol, cortisol/testosterone ratio, and a decrease in TSH, fT3, and fT3/fT4 levels. A set of parameters (T, fT3, fT4, cortisol/testosterone ratio) associated with unstable remission was identified
Alcohol · Blood lipids · Cholesterol · Hormone · Lipid peroxidation · Oxidative stress · Testosterone (patch · Thyroid hormones · Triiodothyronine · Alcohol Consumption and Health Effects · Alcoholism and Thiamine Deficiency · Chemistry · Medicine · Neurological disorders and treatments · Biochemistry · Endocrinology · Internal Medicine
| Highly cited | No |
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