Association between Osteoporosis and Previous Statin Use
A Nested Case-Control Study
Bibliographic Data
| ID | 15460475 |
|---|---|
| Authors | So Young Kim (0000-0003-2258-7490, CHA University Bundang Medical Center), Dae Myoung Yoo (0000-0003-2511-5536, Hallym University), Chanyang Min (0000-0002-0629-9299, Seoul National University), Ji Hee Kim (0000-0001-6937-8093, Hallym University), Mi Jung Kwon (0000-0002-2441-0448, Hallym University), Joo-Hee Kim (0000-0002-3012-5889, Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Hallym University College of Medicine, Anyang 14068, Korea), Joo‐Hee Kim (0000-0002-1572-5149, Hallym University), Hyo Geun Choi (0000-0003-1655-9549, Hallym University, corresponding author) |
| Year | 2021 |
| Volume | 18 |
| Issue | 22 |
| Pages | 11902-11902 |
| Publication date | 2021-11-12 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph182211902 |
| PMID | 34831656 |
| OpenAlex | W3214070675 |
| Language | EN |
| References cited | 28 |
The relationship between statin use and osteoporosis is controversial; therefore, this study aimed to investigate this association. The ≥40-year-old population of the Korean National Health Insurance Service Health Screening Cohort was enrolled. The 68,592 osteoporosis patients were matched 1:1 with control participants for age, sex, income, and region of residence using propensity score matching. The histories of statin use for two years before the diagnosis of osteoporosis (index date) in the osteoporosis and control groups were compared using conditional/unconditional logistic regression. An increased number of days of statin use was not associated with osteoporosis (adjusted OR (aOR) = 0.97, 95% confidence interval (95% CI) = 0.94-1.00, p = 0.052). In the subgroup analyses, a large number of days of statin use was related to a reduced rate of osteoporosis in the <60-year-old female group, while the opposite was true in the ≥60-year-old female group. Both lipophilic and hydrophilic statins were related to a decreased rate of osteoporosis in the <60-year-old female group. Lipophilic statins, but not hydrophilic statins, were associated with an increased rate of osteoporosis in the ≥60-year-old female group. Statin use showed different associations in middle-aged and elderly women
Cohort · Confidence interval · Environmental health · Nested case-control study · Odds ratio · Osteoporosis · Physical therapy · Population · Propensity score matching · Statin · Bone health and osteoporosis research · Cancer, Lipids, and Metabolism · Lipoproteins and Cardiovascular Health · Medicine · Internal Medicine
| Citation velocity | historical |
|---|---|
| Highly cited | No |