Urinary Phthalate Levels Associated with the Risk of Nonalcoholic Fatty Liver Disease in Adults
The Korean National Environmental Health Survey (KoNehs) 2012–2014
Bibliographic Data
| ID | 15460849 |
|---|---|
| Authors | Yun-Jung Yang (0000-0003-0280-5497, Catholic Kwandong University International St. Mary's Hospital), Taehyen Kim (Catholic Kwandong University), Yeon‐Pyo Hong (Chung-Ang University, corresponding author) |
| Year | 2021 |
| Volume | 18 |
| Issue | 11 |
| Pages | 6035-6035 |
| Publication date | 2021-06-04 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph18116035 |
| PMID | 34199698 |
| OpenAlex | W3171067821 |
| Language | EN |
| Citations received | 3 |
| References cited | 2 |
The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing worldwide. Recent experimental studies suggested that phthalates might induce NAFLD. Therefore, this study aimed to investigate the relationship between phthalates metabolites and NAFLD in the human population. This cross-sectional analysis was performed using data from the Korean National Environmental Health Survey II (2012-2014) among Korean adults ( n = 5800). NAFLD was diagnosed using the hepatic steatosis index (HSI) in the absence of other causes of chronic liver diseases. Among the participants (mean age 46 years, 47.5% male), the prevalence of NAFLD was associated with urinary levels of mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono-(2-ethyl-5-oxohexyl) phthalate, mono-(2-ethyl-5-carboxypentyl) phthalate, mono-benzyl phthalate (MBzP), and mono- n -butyl phthalate (MnBP) compared to the reference group. In the multivariate model, the odds ratios (ORs), 95% confidence interval (CI) for NAFLD were 1.33 (1.00-1.78) and 1.39 (1.00-1.92) in the 3rd and 4th quartile of MEHHP, respectively. Based on the study findings, high levels of urinary phthalates are associated with the prevalence of NAFLD in Korean adults. Further investigation is required to elucidate the causal relationship
Body mass index · Confidence interval · Creatinine · Cross-sectional study · Disease · Environmental health · Fatty liver · National Health and Nutrition Examination Survey · Nonalcoholic fatty liver disease · Odds ratio · Pathology · Phthalate · Population · Quartile · Steatosis · Urinary system · Chemistry · Diet and metabolism studies · Effects and risks of endocrine disrupting chemicals · Medicine · Nutritional Studies and Diet · Gastroenterology · Internal Medicine · Physiology
| Unique citing works | 3 |
|---|---|
| Citations per year | 0,75 |
| Citation span | 2022 - 2024 (3) |
| Citation velocity | recent |
| Highly cited | No |
| Citation types | Neutral: 3 |