The Effects of Anterior Cruciate Ligament Reconstruction on Individual Quadriceps Muscle Thickness and Circulating Biomarkers
Bibliographic Data
| ID | 15463141 |
|---|---|
| Authors | Jae‐ho Yang (0000-0001-7421-2805, Inha University), Jae-Ho Yang (Inha University), Seung-Pyo Eun (KOSMED Orthopedic Clinic, Seoul 06014, Korea), Dong‐Ho Park (0000-0003-1863-0652, Inha University), Hyo‐Bum Kwak (0000-0003-0451-4554, Inha University), Eunwook Chang (0000-0001-5876-9275, Inha University, corresponding author) |
| Year | 2019 |
| Volume | 16 |
| Issue | 24 |
| Pages | 4895-4895 |
| Publication date | 2019-12-04 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph16244895 |
| PMID | 31817239 |
| OpenAlex | W2993594711 |
| Language | EN |
| Citations received | 1 |
| References cited | 33 |
Anterior cruciate ligament reconstruction (ACLR) frequently results in quadriceps atrophy. The present study investigated the effect of ACLR on the muscle thickness of the different constituent muscles of the quadriceps and circulating biomarkers related to muscle atrophy and hypertrophy. Fourteen subjects underwent anterior cruciate ligament reconstruction following injury. Quadriceps muscle thicknesses were measured using ultrasound, and circulating biomarkers in the blood were measured using enzyme-linked immunosorbent assays (ELISAs) at the preoperative visit (PRE) and at two postoperative visits (PO1, PO2) in the early stages post-surgery. Differences between time points were analyzed using one-way repeated measures analysis of variance (ANOVA) tests. The most important finding was that severe muscle atrophy occurred in the vastus intermedius (VI) after ACLR (PRE: 20.45 ± 6.82 mm, PO1: 16.05 ± 6.13 mm, PO2: 13.18 ± 4.7 mm, F = 59.0, p < 0.001). Furthermore, the myostatin level was slightly increased, and IGF-1 was significantly reduced throughout the entire period. Therefore, we suggest that inducing selective hypertrophy in the vastus intermedius during the process of rehabilitation would be important for athletes and individuals who engage in explosive sports. Moreover, inhibiting myostatin level increases and maintaining IGF-1 levels in the early phase of recovery after ACLR to prevent muscle atrophy may provide a pharmaceutical option for rehabilitation after anterior cruciate ligament injury
Anterior cruciate ligament · Anterior cruciate ligament reconstruction · Atrophy · Muscle atrophy · Muscle hypertrophy · Myostatin · Physical therapy · Knee injuries and reconstruction techniques · Medicine · Muscle Physiology and Disorders · Sports injuries and prevention · Internal Medicine · Rehabilitation · Surgery
| Citations per year | 0.17 |
|---|---|
| Citation span | 2020 - 2020 (1) |
| Highly cited | No |