Environmental Substances Associated with Alzheimer’s Disease—A Scoping Review
Bibliographic Data
| ID | 15463532 |
|---|---|
| Authors | Hanna Elonheimo (0000-0003-4441-3432, Finnish Institute for Health and Welfare, corresponding author), Helle Raun Andersen (0000-0002-9184-3593, University of Southern Denmark), Andromachi Katsonouri (0000-0003-2038-0648, Ministry of Health), Hanna Tolonen (0000-0003-3121-4303, Finnish Institute for Health and Welfare) |
| Year | 2021 |
| Volume | 18 |
| Issue | 22 |
| Pages | 11839-11839 |
| Publication date | 2021-11-11 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph182211839 |
| PMID | 34831595 |
| OpenAlex | W3213795772 |
| Language | EN |
| Citations received | 1 |
| References cited | 44 |
Alzheimer's disease (AD) is the most common form of dementia, prevalent in approximately 50-70% of the dementia cases. AD affects memory, and it is a progressive disease interfering with cognitive abilities, behaviour and functioning of the person affected. In 2015, there were 47 million people affected by dementia worldwide, and the figure was estimated to increase to 75 million in 2030 and to 132 million by 2050. In the framework of European Human Biomonitoring Initiative (HBM4EU), 18 substances or substance groups were prioritized for investigation. For each of the priority substances, a scoping document was prepared. Based on these scoping documents and complementary review of the recent literature, a scoping review of HBM4EU-priority substances which might be associated with AD was conducted. A possible association between risk of AD and pesticides was detected. For mercury (Hg), association is possible but inconsistent. Regarding cadmium (Cd) and arsenic (As), the results are inconsistent but inclined towards possible associations between the substances and the risk of disease. The evidence regarding lead (Pb) was weaker than for the other substances; however, possible associations exist. Although there is evidence of adverse neurological effects of environmental substances, more research is needed. Environmental chemical exposure and the related hazards are essential concerns for public health, and they could be preventable
Alzheimer's disease · Disease · Environmental health · Pathology · Aluminum toxicity and tolerance in plants and animals · Heavy Metal Exposure and Toxicity · Medicine · Pesticide Exposure and Toxicity
| Unique citing works | 1 |
|---|---|
| Citations per year | 0,25 |
| Citation span | 2022 - 2022 (1) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 1 |