Cell Viability and Immune Response to Low Concentrations of Nickel and Cadmium
An In Vitro Model
Bibliographic Data
| ID | 15464007 |
|---|---|
| Authors | Ahra Kim (0000-0001-5415-5145, Gyeongsang National University), Sangjin Park (0000-0003-1729-399X, Department of Occupational and Environmental Medicine, Soonchunhyang University Hospital Cheonan, College of Medicine, University of Soonchunhyang, Cheonan 31151, Korea), sang-jin Park (0000-0003-4240-5682, Soonchunhyang University Hospital Seoul), Joo Hyun Sung (0000-0001-9043-1127, Gyeongsang National University Hospital, corresponding author) |
| Year | 2020 |
| Volume | 17 |
| Issue | 24 |
| Pages | 9218-9218 |
| Publication date | 2020-12-09 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph17249218 |
| PMID | 33317216 |
| OpenAlex | W3112777393 |
| Language | EN |
| Citations received | 1 |
| References cited | 31 |
Environmental exposure to low concentrations of heavy metals is common in the general population, but the toxicity, immune response mechanisms, and the effects of single and mixed metal exposures have not been clearly identified. In this study, A549 cells and Raw264.7 cells were exposed to low concentrations of the heavy metals nickel (Ni) and cadmium (Cd) for 24, 48, and 72 h, and then cell viability and cytokine levels were analyzed. We found that exposure to low concentrations of Ni (50 nM) or Cd (10 nM) alone did not affect cell viability. However, mixing them together decreased cell viability. In addition, the levels of IL-10, IL-12, and TNF-α decreased with single (only Cd) and mixed (Ni and Cd) exposures. These results show that exposure to low concentrations of heavy metals could affect the normal immune response, even without obvious clinical manifestations. Therefore, chronic exposure to heavy metals might have adverse effects on overall health
Biology · Cadmium · Cell · Heavy metals · Immune system · Nickel · Population · Toxicity · Viability assay · Chemistry · Heavy Metal Exposure and Toxicity · Heavy metals in environment · Immunotoxicology and immune responses · Medicine · Biochemistry · Environmental Chemistry · Immunology · Toxicology
| Citations per year | 0.25 |
|---|---|
| Citation span | 2022 - 2022 (1) |
| Highly cited | No |