Increased Risk of Gastric Cancer in Asbestos-Exposed Workers

A Retrospective Cohort Study Based on Taiwan Cancer Registry 1980–2015

Bibliographic Data

ID15464192
AuthorsYi‐Jen Fang (Kaohsiung Medical University), Yi-Jen Fang (Ph.D. Program in Environmental and Occupational Medicine, College of Medicine, Kaohsiung Medical University and National Health Research Institutes, Kaohsiung 807, Taiwan), Hung-Yi Chuang (0000-0002-8321-8720, Kaohsiung Medical University), Chih‐Hong Pan (Institute of Labor, Occupational Safety And Health, Ministry of Labor), Chih-Hong Pan (Ministry of Labor), Yu‐Yin Chang (National Health Research Institutes), Yu-Yin Chang (0000-0002-8857-0520, National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli County 350, Taiwan), Yawen Cheng (0000-0001-7112-8835, National Taiwan University), Lukas Jyuhn‐Hsiarn Lee (0000-0003-1095-6877, Kaohsiung Medical University, corresponding author), Jung‐der Wang (0000-0002-3176-4500, National Cheng Kung University Hospital)
Year2021
Volume18
Issue14
Pages7521-7521
Publication date2021-07-15
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph18147521
PMID34299971
OpenAlexW3180511404
LanguageEN
References cited22

Asbestos has been recognized as a human carcinogen associated with malignant mesothelioma, cancers of lung, larynx, and ovary. However, a putative association between gastric cancer and asbestos exposure remains controversial. In this study, we aimed to explore gastric cancer risk of workers potentially exposed to asbestos in Taiwan. The asbestos occupational cohort was established from 1950 to 2015 based on the Taiwan Labor Insurance Database, and Taiwan Environmental Protection Agency regulatory datasets, followed by the Taiwan Cancer Registry for the period 1980-2015. Standardized incidence ratios (SIRs) for cancer were computed for the whole cohort using reference rates of the general population, and also reference labor population. Compared with the general population, SIR of the asbestos occupational cohort for the gastric cancer increased both in males (1.05, 95% confidence interval (CI): 1.02-1.09) and females (1.10, 95% CI: 1.01-1.18). A total of 123 worksites were identified to have cases of malignant mesothelioma, where increased risk for gastric cancer was found with a relative risk of 1.76 (95% CI: 1.63-1.90). This 35-year retrospective cohort study of asbestos-exposed workers in Taiwan may provide support for an association between occupational exposure to asbestos and gastric cancer

Asbestos · Cancer · Cancer registry · Cohort · Cohort study · Environmental health · Retrospective cohort study · Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis · Medicine · Metastasis and carcinoma case studies · Occupational and environmental lung diseases · Internal Medicine · Oncology

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