Pre-Pregnancy Maternal Exposure to Persistent Organic Pollutants and Gestational Weight Gain

A Prospective Cohort Study

Bibliographic Data

ID15464367
AuthorsLindsay M Jaacks (0000-0002-7791-5167, Harvard University, corresponding author), Dana Boyd Barr (0000-0002-5566-2138, Emory University), Rajeshwari Sundaram (0000-0002-6918-5002, Biostatistics and Bioinformatics Branch, Division of Intramural Population Health Research), Jagteshwar Grewal (0000-0002-0141-4876, Office of the Director), Cuilin Zhang (0000-0002-8014-2708, Office of Extramural Research), Germaine M Buck Louis (0000-0002-1774-4490), Germaine Buck Louis (Office of the Director)
Year2016
Volume13
Issue9
Pages905-905
Publication date2016-09-12
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph13090905
PMID27626435
OpenAlexW2519969524
LanguageEN
Citations received2
References cited25

Persistent organic pollutants (POPs) have been implicated in the development of obesity in non-pregnant adults. However, few studies have explored the association of POPs with gestational weight gain (GWG), an important predictor of future risk of obesity in both the mother and offspring. We estimated the association of maternal pre-pregnancy levels of 63 POPs with GWG. Data are from women (18-40 years; n = 218) participating in a prospective cohort study. POPs were assessed using established protocols in pre-pregnancy, non-fasting blood samples. GWG was assessed using three techniques: (1) total GWG (difference between measured pre-pregnancy weight and final self-reported pre-delivery weight); (2) category based on pre-pregnancy body mass index (BMI)-specific Institute of Medicine (IOM) recommendations; and (3) area under the GWG curve (AUC). In an exploratory analysis, effects were estimated separately for women with BMI < 25 kg/m2 versus BMI ≥ 25 kg/m2. Multivariable polytomous logistic regression and linear regression were used to estimate the association between each chemical or congener and the three GWG outcomes. p,p'-dichlorodiphenyl trichloroethane (p,p'-DDT) was significantly inversely associated with AUC after adjustment for lipids and pre-pregnancy BMI: beta {95% confidence interval (CI)}, -378.03 (-724.02, -32.05). Perfluorooctane sulfonate (PFOS) was significantly positively associated with AUC after adjustment for lipids among women with a BMI < 25 kg/m2 {beta (95% CI), 280.29 (13.71, 546.86)}, but not among women with a BMI ≥ 25 kg/m2 {beta (95% CI), 56.99 (-328.36, 442.34)}. In summary, pre-pregnancy levels of select POPs, namely, p,p'-DDT and PFOS, were moderately associated with GWG. The association between POPs and weight gain during pregnancy may be more complex than previously thought, and adiposity prior to pregnancy may be an important effect modifier

Biology · Body mass index · Body weight · Cohort · Cohort study · Confidence interval · Gestation · Obesity · Obstetrics · Perfluorooctane · Pregnancy · Prospective cohort study · Weight gain · Birth, Development, and Health · Chemistry · Gestational Diabetes Research and Management · Medicine · Per- and polyfluoroalkyl substances research · Internal Medicine