Functional Gene Clusters in Global Pathogenesis of Clear Cell Carcinoma of the Ovary Discovered by Integrated Analysis of Transcriptomes
Bibliographic Data
| ID | 15464381 |
|---|---|
| Authors | Yueh-Han Hsu (0000-0002-4142-4876, National Yang Ming Chiao Tung University), Peng‐Hui Wang (0000-0002-6048-8541, National Yang Ming Chiao Tung University), Chia-Ming Chang (0000-0003-0390-6361, National Yang Ming Chiao Tung University, corresponding author) |
| Year | 2020 |
| Volume | 17 |
| Issue | 11 |
| Pages | 3951-3951 |
| Publication date | 2020-06-02 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph17113951 |
| PMID | 32498447 |
| OpenAlex | W3032939302 |
| Language | EN |
| References cited | 5 |
Clear cell carcinoma of the ovary (ovarian clear cell carcinoma (OCCC)) is one epithelial ovarian carcinoma that is known to have a poor prognosis and a tendency for being refractory to treatment due to unclear pathogenesis. Published investigations of OCCC have mainly focused only on individual genes and lack of systematic integrated research to analyze the pathogenesis of OCCC in a genome-wide perspective. Thus, we conducted an integrated analysis using transcriptome datasets from a public domain database to determine genes that may be implicated in the pathogenesis involved in OCCC carcinogenesis. We used the data obtained from the National Center for Biotechnology Information (NCBI) Gene Expression Omnibus (GEO) DataSets. We found six interactive functional gene clusters in the pathogenesis network of OCCC, including ribosomal protein, eukaryotic translation initiation factors, lactate, prostaglandin, proteasome, and insulin-like growth factor. This finding from our integrated analysis affords us a global understanding of the interactive network of OCCC pathogenesis
Bioinformatics · Biology · Carcinogenesis · Carcinoma · Clear cell carcinoma · Computational biology · Gene · Gene expression · Pathogenesis · Transcriptome · Cancer-related molecular mechanisms research · Ovarian cancer diagnosis and treatment · Reproductive System and Pregnancy · Cancer Research · Genetics · Immunology
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| Highly cited | No |
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