Excess Body Weight and Long-Term Incidence of Lung and Colon Cancer in Men; Follow-Up Study of 43 Years
Bibliographic Data
| ID | 15464428 |
|---|---|
| Authors | Yftach Gepner (0000-0001-9633-6497, Tel Aviv University, corresponding author), Shahar Lev‐Ari (0000-0003-0187-9427, Tel Aviv University), Uri Goldbourt (Tel Aviv University) |
| Year | 2021 |
| Volume | 18 |
| Issue | 19 |
| Pages | 10418-10418 |
| Publication date | 2021-10-03 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph181910418 |
| PMID | 34639717 |
| OpenAlex | W3204255374 |
| Language | EN |
| References cited | 27 |
Most evidence for an association between excess body weight and cancer risk has been derived from studies of relatively short duration with little reference to the effect on tumor site. This study was designed to evaluate the association between categories of body mass index (BMI: 30 kg/m 2 ) and the incidence of colon and lung cancer over 43 years of follow-up (1963-2006), in 10,043 men from the Israeli Ischemic Heart Disease (IIHD) prospective cohort (mean age at baseline 49.3 years, mean BMI 25.7 kg/m 2 ). Data from the Israel National Cancer Registry was linked with the IIHD, and the Cox proportional hazards regression model was applied to analyze the relative risks for lung and colon cancer across BMI categories at baseline. Three hundred cases of lung cancer (2.9%) and 328 cases of colon cancer (3.3%) were diagnosed in the total population. Applying a multivariate model adjusted for age, smoking intensity, and total cholesterol, higher BMI category was associated with an increased risk of colon cancer [HR = 1.22 (95% CI 1.02-1.45)], and with a decreased risk for lung cancer [HR = 0.66 (95% CI 0.56-0.77)]. In this long-term follow-up study over four decades, we observed a consistent dose-response pattern between BMI and increased risk for colon cancer, but decreased risk for lung cancer. Specific associations between excess body weight and cancer risk may suggest different patterns of body fat and cancer incidence at a given site
Body mass index · Cancer · Cancer registry · Cohort · Cohort study · Colorectal cancer · Confidence interval · Environmental health · Incidence (geometry · Lung cancer · Population · Proportional hazards model · Prospective cohort study · Relative risk · Cancer Risks and Factors · Medicine · Multiple and Secondary Primary Cancers · Nutrition and Health in Aging · Internal Medicine · Oncology
Obesity and Cardiovascular Disease: Pathophysiology, Evaluation, and Effect of Weight Loss
Overweight, Obesity, and Mortality from Cancer in a Prospectively Studied Cohort of U.S. Adults
Body-mass index and incidence of cancer
Body-mass index and cause-specific mortality in 900 000 adults
Global Cancer Statistics 2020
Validity of self-reported height and weight in 4808 Epic–Oxford participants
| Citation velocity | historical |
|---|---|
| Highly cited | No |