Cognitive Function and Whole-Brain MRI Metrics Are Not Associated with Mobility in Older Adults with Multiple Sclerosis
Bibliographic Data
| ID | 15464482 |
|---|---|
| Authors | Jessica F Baird (0000-0002-0691-049X, University of Alabama at Birmingham, corresponding author), Robert W Motl (0000-0002-5894-2290, University of Alabama at Birmingham, corresponding author) |
| Year | 2021 |
| Volume | 18 |
| Issue | 8 |
| Pages | 4232-4232 |
| Publication date | 2021-04-16 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph18084232 |
| PMID | 33923592 |
| OpenAlex | W3156857526 |
| Language | EN |
| References cited | 48 |
Due to advances in disease-modifying medications and earlier management of comorbidities, adults with multiple sclerosis (MS) are living longer, and this coincides with the aging of the general population. One major problem among older adults with and without MS is limited mobility, a consequence of aging that often negatively affects quality of life. Identifying factors that contribute to mobility disability is needed to develop targeted rehabilitation approaches. This study examined cognitive processing speed and global brain atrophy as factors that may contribute to mobility disability in older adults with and without MS. Older adults (≥55 years) with MS ( n = 31) and age- and sex-matched controls ( n = 22) completed measures of mobility (Short Physical Performance Battery) and cognitive processing speed (Symbol Digit Modalities Test) and underwent an MRI to obtain whole-brain metrics (gray matter volume, white matter volume, ventricular volume) as markers of atrophy. Mobility was significantly worse in the MS group than in the control group ( p = 0.004). Spearman correlations indicated that neither cognitive processing speed (MS: r s = 0.26; Control: r s = 0.08) nor markers of global brain atrophy (MS: r s range = -0.30 to -0.06; Control: r s range = -0.40 to 0.16) were significantly associated with mobility in either group. Other factors such as subcortical gray matter structures, functional connectivity, exercise/physical activity, and cardiovascular fitness should be examined as factors that may influence mobility in aging adults with and without MS
Atrophy · Brain size · Cognition · Magnetic resonance imaging · Multiple sclerosis · Physical medicine and rehabilitation · Physical therapy · Population · Psychiatry · White matter · Cerebral Palsy and Movement Disorders · Effects of Vibration on Health · Medicine · Multiple Sclerosis Research Studies · Psychology · Gerontology · Internal Medicine
Statistical Power Analysis for the Behavioral Sciences
Rating neurologic impairment in multiple sclerosis
Lower-Extremity Function in Persons over the Age of 70 Years as a Predictor of Subsequent Disability
Fast robust automated brain extraction
A Short Physical Performance Battery Assessing Lower Extremity Function
Health-related quality of life in relation to walking habits and fitness
| Citation velocity | historical |
|---|---|
| Highly cited | No |