Lack of Associations between Environmental Exposures and Environmental Enteric Dysfunction among 18-Month-Old Children in Rural Malawi
Bibliographic Data
| ID | 15464709 |
|---|---|
| Authors | Zhifei Liu (0000-0002-5202-6283, Tampere University, corresponding author), Yue-Mei Fan (0000-0002-3241-6225, Tampere University), Per Ashorn (0000-0003-2311-2593, Tampere University), Chilungamo Chingwanda (Kamuzu Central Hospital), Kenneth Maleta (0000-0002-2536-3938, Kamuzu Central Hospital), Lotta Hallamaa (0000-0001-9211-3288, Tampere University), Heikki Hyöty (0000-0003-0370-4145, Tampere University), David Chaima (0000-0002-5480-7542, Kamuzu Central Hospital), Ulla Ashorn (0000-0002-1720-868X, Tampere University) |
| Year | 2022 |
| Volume | 19 |
| Issue | 17 |
| Pages | 10891-10891 |
| Publication date | 2022-09-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph191710891 |
| PMID | 36078607 |
| OpenAlex | W4294252523 |
| Language | EN |
| References cited | 52 |
Environmental enteric dysfunction (EED) is common and contributes to linear growth faltering (stunting) and mortality among children in low-resource settings. A few studies on the environmental causes of EED have been conducted but the exact exposures that cause or predispose children to EED are context-specific and not clear. This study aimed to assess associations between selected environmental exposures and EED markers among 620 18-month-old children. This was a secondary analysis of data from Malawian children who participated in a randomized controlled trial (iLiNS-DYAD, registered at clinicaltrials.gov as NCT01239693) from birth to 18 months of age. Data on environmental exposures, including drinking water source, sanitation, exposure to animals, housing materials, season, residential area, and food insecurity were collected at enrolment. Biomarkers of EED included concentrations of calprotectin, regenerating 1B protein (REG1B), and alpha-1-antitrypsin from stool samples to assess intestinal inflammation, repair, and permeability, respectively. We performed bivariate and multivariable analyses to assess associations between environmental exposures and EED biomarkers. Adjusting for possible confounders, we did not find associations between the selected environmental exposures and the three biomarkers. These results do not provide support for our hypothesis that the studied adverse environmental exposures are associated with increased concentrations of children's EED markers in rural Malawi
Biology · Calprotectin · Confounding · Context (archaeology · Disease · Environmental health · Pathology · Sanitation · Child Nutrition and Feeding Issues · Child Nutrition and Water Access · Infant Nutrition and Health · Medicine · Internal Medicine
WHO Child Growth Standards based on length/height, weight and age
Household Food Insecurity Access Scale (HFIAS) for Measurement of Food Access: Indicator Guide: Version 3
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Bayesian geostatistical modelling of stunting in Rwanda
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| Citation velocity | historical |
|---|---|
| Highly cited | No |