Maternal Iron Deficiency Programs Offspring Cognition and Its Relationship with Gastrointestinal Microbiota and Metabolites

Bibliographic Data

ID15465970
AuthorsHsin-Yi Hsieh (0000-0002-2762-8856, Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan), Hsin‐Yi Hsieh (Chang Gung University), Yu‐Chieh Chen (0000-0002-2597-7577, Chang Gung University), Yu-Chieh Chen (Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan), Mei‐Hsin Hsu (Chang Gung University), Mei-Hsin Hsu (Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan), Hong‐Ren Yu (0000-0003-1242-8760, Chang Gung University), Chung‐Hao Su (Chang Gung University), Chung-Hao Su (Department of Pediatrics, Chiayi Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Chiayi 613, Taiwan), You‐Lin Tain (0000-0002-7059-6407, Chang Gung University), Li‐Tung Huang (0000-0001-7403-288X, Chang Gung University, corresponding author), Jiunn‐Ming Sheen (0000-0002-1581-0052, Chang Gung University, corresponding author), Jiunn-Ming Sheen (Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan)
Year2020
Volume17
Issue17
Pages6070-6070
Publication date2020-08-20
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph17176070
PMID32825437
OpenAlexW3075375009
LanguageEN
References cited40

Iron is an essential micronutrient for the brain development of the fetus. Altered intestinal microbiota might affect behavior and cognition through the so-called microbiota-gut-brain axis. We used a Sprague-Dawley rat model of a maternal low-iron diet to explore the changes in cognition, dorsal hippocampal brain-derived neurotrophic factor (BDNF) and related pathways, gut microbiota, and related metabolites in adult male offspring. We established maternal iron-deficient rats by feeding them a low-iron diet (2.9 mg/kg), while the control rats were fed a standard diet (52.3 mg/kg). We used a Morris water maze test to assess spatial learning and long-term memory. Western blot (WB) assays and a quantitative reverse-transcription polymerase chain reaction (qRT-PCR) were used to detect the BDNF concentration and related signaling pathways. We collected fecal samples for microbiota profiling and measured the concentrations of plasma short-chain fatty acids. The adult male offspring of maternal rats fed low-iron diets before pregnancy, during pregnancy and throughout the lactation period had (1) spatial deficits, (2) a decreased BDNF mRNA expression and protein concentrations, accompanied by a decreased TrkB protein abundance, (3) a decreased plasma acetate concentration, and (4) an enrichment of the Bacteroidaceae genus Bacteroides and Lachnospiraceae genus Marvinbryantia . Maternal iron deficiency leads to an offspring spatial deficit and is associated with alternations in gastrointestinal microbiota and metabolites

Bacteroidaceae · Biology · Brain-derived neurotrophic factor · Firmicutes · Gut flora · Gut–brain axis · Lachnospiraceae · Lactation · Neurotrophic factors · Offspring · Pregnancy · Tropomyosin receptor kinase B · Child Nutrition and Water Access · Gut microbiota and health · Iron Metabolism and Disorders · Medicine · Biochemistry · Endocrinology · Genetics · Immunology · Internal Medicine · Physiology

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