Differences in Incidence and Risks of Suicide Attempt and Suicidal Drug Overdose between Patients with Epilepsy with and without Comorbid Depression
Bibliographic Data
| ID | 15466404 |
|---|---|
| Authors | Chi-Yu Lin (China Medical University), Tomor Harnod (Tzu Chi University), Cheng‐Li Lin (0000-0001-9926-3668, China Medical University), Wei‐Chih Shen (Asia University), Wei-Chih Shen (Asia University), Chia‐Hung Kao (0000-0002-6368-3676, Asia University, corresponding author) |
| Year | 2019 |
| Volume | 16 |
| Issue | 22 |
| Pages | 4533-4533 |
| Publication date | 2019-11-15 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph16224533 |
| PMID | 31731830 |
| OpenAlex | W2983332546 |
| Language | EN |
| References cited | 23 |
Objective : To determine the differences in the incidences and risks of suicide attempt (SA) and suicidal drug overdose (SDO) between patients with epilepsy with and without comorbid depression by using data from Taiwan's National Health Insurance Research Database. Methods : We analyzed data of patients (≥20 years) who had received epilepsy diagnoses between 2000 and 2012; the diagnosis date of epilepsy was defined as the index date. The epilepsy patients were divided into the cohorts, with and without comorbid depression, and compared against a cohort from the non-affected population. We calculated adjusted hazard ratios and the corresponding 95% confidence intervals for SA and SDO in the three cohorts after adjustment for age, sex, and comorbidities. Results : The incidences of SA and SDO in the cohort with epilepsy and depression were 42.9 and 97.4 per 10,000 person-years, respectively. The epilepsy with depression cohort had 21.3 times of SA risk; and 22.9 times of SDO risk than did the comparison cohort had a 6.03-fold increased risk of SA and a 2.56-fold increased risk of SDO than did the epilepsy patients without depression. Moreover, patients' age Conclusion : Risks of SA and SDO in patients with epilepsy are proportionally increased when depression is coexisted. Our findings provide crucial information for clinicians and the government for suicide prevention and to question whether prescribing a large number of medications to patients with epilepsy and depression is safe
Cohort · Cohort study · Comorbidity · Confidence interval · Depression (economics · Environmental health · Epilepsy · Hazard ratio · Incidence (geometry · Population · Psychiatry · Epilepsy research and treatment · Medicine · Pharmacological Effects and Toxicity Studies · Pharmacological Receptor Mechanisms and Effects · Internal Medicine
| Citation velocity | historical |
|---|---|
| Highly cited | No |